参芪地黄汤加减治疗2型糖尿病合并膜性肾病30例临床观察

Investigation of Shenqi Dihuang decoction on the treatment of type 2 diabetes with membranous nephropathy

目的观察参芪地黄汤加减治疗2型糖尿病合并膜性肾病临床疗效。方法将60例2型糖尿病合并膜性肾病患者随机分为2组。对照组30例予西医常规治疗,治疗组30例在对照组治疗基础上加用参芪地黄汤加减治疗。2组均3个月为1个疗程,1个疗程后统计疗效,并观察2组治疗前后中医证候积分、24 h尿蛋白定量(24Upro)、血清白蛋白(Alb)、血清肌酐(Cr)、糖化血红蛋白(HbAlc)及总胆固醇(TC)。结果2组中医、西医总有效率比较差异均有统计学意义(P<0.05),治疗组疗效优于对照组。2组治疗后中医证候积分、24Upro均降低(P<0.05),且治疗组降低优于对照组(P<0.05);2组治疗后Alb均升高(P<0.05),且治疗组升高优于对照组(P<0.05)。2组治疗后Cr、HbAlc及TC与本组治疗前及组间比较差异无统计学意义(P>0.05)。结论参芪地黄汤加减治疗2型糖尿病合并膜性肾病疗效确切。

Objective To investigate the clinical effect of Shenqi Dihuang decoction on the treatment of type 2 diabetes with membranous nephropathy. Methods 60 cases of type 2 diabetes with membranous nephropathy were randomly divided into two groups. Patients in control group （ n = 30） were treated by western conventional treatment. Patients in treatment group （ n = 30 ） were treated by Shenqi Dihuang decoction on the basis of control group treatment. The course was three months in two groups. The therapeutic effect was evaluated after a course. TCM score, 24 Upro,Alb,Cr,HbAlc and TC in serum were observed before and after treatment in two groups. Results There was significant difference between western medicine and traditional Chinese medicine on the total effective rate in two groups （ P 〈 0.05 ）. The therapeutic effect in treatment group was superior to that in control group. TCM score and 24 Upro after treatment were decreased in two groups （ P 〈 0.05 ）. The decrease in treatment group was superior to that in control group （ P 〈 0.05 ）. Alb after treatment were increased in two groups （ P 〈 0.05 ）. The increase in treatment group was superior to that in control group （ P 〈 0.05 ）. There was no significant difference between before and after treatment on Cr, HbAlc and Alb in two groups （P 〉 0.05 ）. Conclusion Shenqi Dihuang decoction has definite effect on the treatment of type 2 diabetes with membranous nephropathy.