摘要
采用UFLC-Q-TOF-MS/MS技术,在正离子模式下,根据各物质的质谱裂解规律,研究鉴定出盐酸克林霉素棕榈酸酯分散片中16种杂质,其中克林霉素九酸酯、克林霉素十酸酯、克林霉素十一酸酯、克林霉素十三酸酯为首次检到,本研究为其质量监控提供了实验依据。
Sixteen impurities in clindamycin palmitate hydrochloride dispersible tablets were identified according to their fragmentation patterns and characteristic fragment ions by UFLC-Q-TOF-MS/MS in a positive mode .Among them , clindamycin nonanoate , clindamycin decanoate , clindamycin monodecano-ate, clindamycin tridecanoate were firstly detected .These results provided a basis for quality control of clindamycin palmitate hydrochloride dispersible tablets .
出处
《中山大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第4期101-106,共6页
Acta Scientiarum Naturalium Universitatis Sunyatseni
基金
广东省科技计划资助项目(2012B090600020)
关键词
盐酸克林霉素棕榈酸酯分散片
杂质
液质联用分析
clindamycin palmitate hydrochloride dispersible tablets impurities LC-MS analysis
