老年慢性肾衰竭患者血清胱抑素C检测的临床意义

Serum Cystatin C Testing in Old Patients with Chronic Renal Failure

目的探讨血清胱抑素C检测对老年慢性肾衰竭患者的临床意义。方法98例老年慢性肾衰竭患者为观察组，同期进行健康体检的36例老年人为对照组，两组均进行血清胱抑素c、肌酐和尿素氮检测，并比较分析。结果观察组血清胱抑素C、肌酐和尿素氨水平均显著高于对照组（P〈0．01）。观察组中Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期患者血清胱抑素C、肌酐和尿素氮水平比较，差异均有统计学意义（Ⅰ期〈Ⅱ期〈Ⅲ期〈Ⅳ期，P〈0．01）。在Ⅰ期患者中，胱抑素c检测的阳性率明显高于肌酐和尿素氮（P〈0．05）。结论血清胱抑素C可作为早期诊断老年慢性肾衰竭的敏感指标，并对判断病情严重程度有重要价值。

Objective To investigate the clinical significance of serum cystatin C（Cys-C） testing in old patients with chronic renal failure（CRF）. Methods 98 patients with CRF were observation group. 36 healthy old people were served as the control. The levels of serum Cys-C, Scr, and BUN of the 2 groups were tested and compared. Results The levels of serum Cys-C, Scr, and BUN of the observation group were significantly higher than those of the control（P〈0.01）. There were significantly differences among period Ⅰ, period Ⅱ, period Ⅲ, and period Ⅳ patients in the observation group about the levels of Cys-C, Scr, and BUN（P〈0.01）. Positive rate of Cys-C testing in period Ⅰ group was significantly higher than those of Scr and BUN（P〈0.05）. Conclusion Serum Cys-C could be a sensitive indicator for early diagnosis in old patients with CRF, and it had an important value to evaluate the severity of the disease.