莫沙必利联合奥美拉唑治疗胃食管反流病的临床研究

Clinical Trial of Mosapride Combined with Omeprazole in Treatment of Gastroesophageal Reflux Disease

目的:评价莫沙必利与奥美拉唑联合用药治疗胃食管反流病(GERD)的疗效与不良反应。方法:将80例GERD患者随机分为治疗组和对照组(各40例)。治疗组服用奥美拉唑(20 mg,bid)+莫沙必利(5 mg,tid),对照组服用莫沙必利(5 mg,tid),疗程均为8周。治疗结束后比较两组患者的常见症状缓解率以及药物的不良反应,并通过胃镜观察比较有效率。结果:治疗8周后,治疗组患者烧心、反酸、反流、胸痛等症状的平均缓解率高于对照组患者(85.7%vs.63.3%,P<0.05),镜下有效率高于对照组患者(77.5%vs.52.5%,P<0.05),差异均有统计学意义。治疗过程中,患者耐受均良好,无严重不良反应。结论:莫沙必利联合奥美拉唑治疗GERD可达到较高的症状缓解率和镜下有效率,临床疗效、安全性均较好。

OBJECTIVE：To evaluate the efficacy and safety of mosapride combined with omeprazole in treatment of gastro-esophageal reflux disease. METHODS：80 patients with gastroesophageal reflux disease were randomly divided into a treatment group（n=40）and control group（n=40）. Treatment group was given omeprazole（20 mg,bid）plus mosapride（5 mg,tid）while the control group was given mosapride（5 mg,tid）for 8 weeks. After treatment completion,the rate of patients showing relief of common symptoms and the adverse drug reactions were compared between the two groups;and the effective rate was evaluated by gastroscopy. RESULTS：After 8-week treatment,the patients in the treatment group showed high rate of relief of common symp-toms including heartburn,sour regurgitation,chest pain and other symptoms than in the control group on average （85.7% vs. 63.3%,P〈0.05）,and the effective rate evaluated by gastroscopy was also higher than in the control group（77.5% vs. 52.5%,P〈0.05）. During treatment,all of the patients were well tolerated,with no serious adverse reactions noted. CONCLUSIONS：Mo-sapride combined with omeprazole resulted in high rate of symptom relief and high effective rate gastroscopically with good clinical efficacy and safety in patients with gastroesophageal reflux disease.