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白细胞介素4受体基因3个多态位点与哮喘的相关性研究

Association study between polymorphism of interleukin-4 receptor gene and bronchial asthma
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摘要 目的探讨白细胞介素4受体(interleukin-4 receptor,IL-4R)基因多态性与青岛地区汉族成人哮喘的相关性。方法采用SNaP shot单核苷酸多态性(single nucleotide polymorphisms,SNP)分型技术对400例哮喘患者和200名正常对照的IL-4R基因rs3024619、rs2057768和rs3024585共3个多态位点的基因多态性进行检测。结果 IL-4R基因rs3024619、rs2057768和rs3024585共3个多态位点的基因型频率分布在对照组与哮喘组间差异无统计学意义(P>0.05)。结论 IL-4R基因3个多态位点(rs3024619、rs2057768和rs3024585)与青岛地区汉族成人哮喘不存在相关性。 Objective To assess the association between polymorphism of interleukin-4 receptor gene and bronchial asthma in a population of Han nationality in Qingdao. Methods Three polymorphism sites, rs3024619, rs2057768 and rs3024585, were detected by Snapshot. Results About rs3024619, rs2057768 and rs3024585, there was no significant difference between the asthma group and the control group in the frequencies of genotypes （ P〉0. 05）. Conclusion The study shows that the polymorphisms of IL-4R （rs3024619, rs2057768 and rs3024585） is not associated with asthma in Han nationality in Qingdao.
作者 周兆山 王燕青 吉中强 薛卫林 张小燕 梁文华
机构地区 青岛市海慈医疗集团肺病科 青岛市海慈医疗集团心内科 生物芯片国家工程研究中心
出处 《临床肺科杂志》 2014年第9期1553-1555,共3页 Journal of Clinical Pulmonary Medicine
基金 国家自然科学基金资助项目(No C190401)
关键词 哮喘 IL-4R基因 单核苷酸多态性 关联研究 asthma interleukin-4 receptor gene single nucleotide polymorphisms association analysis
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献14

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临床肺科杂志
2014年 第9期

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