肺部真菌感染42例临床分析

Clinical analysis of 42 patients with pulmonary fungal infection

目的对肺部真菌感染的临床特点、诊断及治疗结果进行分析。方法呼吸内科近3年来收治的肺部真菌感染的患者病历资料,包括患者的基础疾病、感染的真菌种类以及治疗结果等进行分析。结果近3年来,共有42例患者诊断为肺部真菌感染。其中,肺孢子菌感染16例(38.10%),白色假丝酵母菌12例(28.57%),曲霉菌感染9例(21.43%),克柔假丝酵母菌1例(2.38%),热带假丝酵母菌1例(2.38%),光滑念珠菌1例(2.38%),奴卡菌1例(2.38%),近平滑假丝酵母菌1例(2.38%)。患者免疫缺陷或机体免疫力低下占32例(76.20%)。结论肺部真菌感染患者多有基础疾病或免疫缺陷,本组患者肺部感染的常见真菌为肺孢子菌,治疗效果与患者基础疾病及免疫状况有关。

Objective To analyze the clinical features, diagnosis and treatment of pulmonary fungal infec-tion. Methods The clinical data of patients with pulmonary fungal infection were retrospectively analyzed, including primary diseases, fungal species, and the results of treatment. Results In the past three years, a total of 42 patients were diagnosed as pulmonary fungal infection. Pulmonary pneumocystis infection was diagnosed in 16 cases （38. 10%）, candida albicans in 12 cases （28. 57%）, and aspergillus infection in 9 cases （21. 43%）. Others were candida krusei （1 case, 2. 38%）, candida tropicalis （1 case, 2. 38%）, smooth candida （1 case, 2. 38%）, pul-monary nocardiosis （1 case, 2. 38%）, and candida parapsilosis （1 case, 2. 38%）. 32 cases （76. 20%） had an immune deficiency or disturbance. Conclusion Patients with immunodeficiency or chronic diseases are apt to suffer from pulmonary fungal infection. Pneumocystis, candida albicans, and aspergillus are the most common species in pulmonary fungal infections. Prognosis is correlated to the fungal species, primary diseases, and immune status.