肺腺癌患者血清CEA和糖链抗原肿瘤标记物联合测定的临床意义

Clinical significant of combined determination of serum CEA and carbohydrate antigen tumor markers in 85 patients with lung adenocarcinoma

目的为了探讨85例肺腺癌患者血清CEA和糖链抗原肿瘤标记物水平联合测定的临床意义。方法化学发光免疫分析测定85例肺腺癌、35例肺鳞癌、42例小细胞肺癌和49例良性肺部疾病血清CEA和糖链抗原(CA125、CA199和CA153)水平,并进行了比较性研究。结果 162例肺癌患者中,85例肺腺癌、35例肺鳞癌、42例小细胞肺癌患者血清CEA水平较之49例良性肺部疾病明显增高(P<0.001、P<0.01和P<0.001),以肺腺癌增高最为明显。血清糖链抗原(CA125、CA199和CA153)水平亦然,也以肺腺癌血清CA125、CA199和CA153水平增高最为显著。四项肿瘤标记物的联合测定对85例肺腺癌的敏感性为95.29%和准确性83.76%较之单项肿瘤标记物明显增高(P均<0.01),而特异性为75.23%适中。结论四项肿瘤标记物血清CEA和糖链抗原(CA125、CA199和CA153)水平的联合测定,是诊断肺腺癌的有效指标,而且提高了敏感性和准确性。

Objective To explore the clinical significant of combined determination of serum CEA and car-bohydrate antigen （CA125, CA199, CA153） tumor markers in patients with lung adenocarcinoma. Methods The serum CEA and carbohydrate antigen （CA125, CA199 and CA153） levels were determined with chemilumescence immunoassay in 85 patients with lung adenocarcinoma, 35 patients with lung squanous carcinoma, 42 patients with small cell lung cancer and 49 patients with benign lung disease. Results In 162 patients with lung cancer, the serum CEA and carbohydrate antigen levels were significantly higher in 85 patients with lung adenocarcinoma, 35 pa-tients with lung squanous carcinoma and 42 patients with small cell lung cancer than those in 49 patients with benign lung disease （P〈0. 001） and the level of 85 patients with lung adenocarcinoma was the highest. So did the serum carbohydrate antigen levels. The sensitivity （95. 29%） and accuracy （83. 76%） in the four tumor markers combined determination were significantly higher than those in single item （ P all〈0. 01 ） , and the specificity was 75. 23%.Conclusion The combined detection of serum CEA and carbohydrate antigen levels is helpful for the diagnosis of lung adenocarcinoma, with higher sensitivity and accuracy.