肺癌患者血清中MIC-1浓度检测的临床意义

Clinical significance of serum macrophage inhibitory factor-1 in patients with pulmonary carcinoma

目的观察研究肺癌患者血清中巨噬细胞抑制因子-1(MIC-1)浓度的检测价值。方法选择2010年2月～2013年于本院进行诊治的78例肺癌患者为观察组,同时期的80例健康者为对照组,对两组被检者均进行巨噬细胞抑制因子-1(MIC-1)血清浓度、CEA、CA199及AFP检测,并比较检测结果。结果观察组的血清MIC-1及CEA、CA199、AFP浓度高于对照组,P<0.05,且观察组患者TNM分期较高,血清MIC-1及CEA、CA199、AFP浓度高于分期较低者,P<0.05,均有显著性差异。结论 MIC-1浓度可以作为肺癌患者诊断的参考指标,其与CEA、CA199及AFP的检测价值均较高。

Objective To observe and study the detection value of serum macrophage inhibitory factor-1 （MIC-1） in patients with pulmonary carcinoma. Methods 78 patients with pulmonary carcinoma in our hospital were selected in the observation group, and 80 healthy people at the same time were taken as the control group. Their serum MIC-1, CEA, CA199 and AFP were detected, and the detection results were compared. Results The levels of serum MIC-1, CEA, CA199 and AFP were higher in the observation group than in the control group （P〈0. 05）, and they were higher in patients with advanced TNM stages than in those with lower stages （all P〈0. 05）. Conclu-sion The serum MIC-1 can be as the diagnostic reference index of patients with pulmonary carcinoma, and the diag-nose value of MIC-1, CEA, CA199 and AFP is all higher.