不同严重程度OSAHS伴慢阻肺对患者认知功能的影响

Influence of different degrees of OSAHS associated with chronic obstructive pulmonary disease on cognitive function

目的探讨不同严重程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)伴慢阻肺对患者认知功能影响。方法入住的116例OSAHS伴慢阻肺患者,依据睡眠呼吸暂停低通气指数(AHI)分为轻、中、重3组。进行简易智能精神状态检查量表(MMSE)检测,分析各组患者认知障碍发生情况。结果重度OSAHS伴慢阻肺组MMSE总分明显低于轻、中度OSAHS伴慢阻肺组,在记忆力、注意力和计算力、回忆能力得分明显低于轻、中度OSAHS伴慢阻肺组,差异有显著性统计学意义(P<0.05);轻、中度OSAHS组MMSE总分及在记忆力、注意力和计算力、回忆能力得分比较,差异无统计学意义(P>0.05)。结论重度OSAHS伴慢阻肺患者较轻、中度OSAHS患者认知功能明显下降,主要表现在记忆、计算、回忆方面的损害。

Objective To explore the influence of different degrees of obstructive sleep apnea hypopnea syn-drome （ OSAHS） associated with chronic obstructive pulmonary disease on cognitive function. Methods According to apnea hypopnea index （ AHI） , 116 patients with OSAHS associated with COPD were divided into the mild, moder-ate and severe groups. And then cognitive disorder in patients of each group was analyzed by the mini-mental state ex-amination （ MMSE） detection. Results The MMSE total score of the severe group was significantly lower than that in the mild group and the moderate group, and so did the scores in memory, attention, computing power and memory ability （P〈0. 05）. But there was no significant difference between the mild group and the moderate group （P〉0. 05）. Conclusion Compared with mild and moderate patients, the cognitive function of severe patients with OS-AHS and COPD declines obviously, which is mainly reflected in the memory, calculation, and memory ability.