OSAHS患者呼出气冷凝液中MMP-9的变化

Changes of MMP-9 in exhaled breath condensate of patients with obstructive sleep apnea hypopnea syndrome

目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者呼出气冷凝液(EBC)中基质金属蛋白酶9(MMP-9)的变化。方法选取男性40例OSAHS患者为实验组,30例年龄、体重指数等均相匹配的健康查体者为对照组,用ELISA检测EBC中MMP-9水平。结果和对照组比较,OSAHS组EBC中MMP-9明显升高,有显著统计学意义(P<0.05)。MMP-9与AHI呈正相关,与最低SaO2负相关(P均<0.05)。结论OSAHS患者EBC中MMP-9水平可反映OSAHS病情的严重程度。

Objective To evaluate the changes of matrix metalloproteases-9（MMP-9）in exhaled breath con-densate（ EBC） with Obstructive sleep apnea-hypopnea syndrome （ OSAHS） . Methods Select 40 males and OSAHS patients for the experimental group, 30 healthy subjects matched age and body mass index as a control group. exhaled breath condensate The levels of MMP-9 in EBC were determined by ELISA. Results Compared to the control group, the MMP-9 in OSAHS group was significantly higher （ P〈0. 05 ） . MMP-9 was positively correlated with AHI （ P〈0. 05）, and negative correlated the lowest SaO2（P〈0. 05）. Conclusion The MMP-9 levels in EBC in OSAHS pa-tients may reflect the severity of OSAHS.