5-氨基酮戊酸光动力疗法治疗尖锐湿疣的临床研究

Clinical observation on ALA-PDT in the treatment of condyloma acuminatum

目的观察5-氨基酮戊酸光动力疗法(ALA-PDT)治疗尖锐湿疣的临床疗效。方法将55例尖锐湿疣患者分为两组,试验组(26例)采用ALA-PDT治疗,对照组(29例)采用液氮冷冻治疗,并于末次治疗后12周进行疗效评估,比较两组治疗后的复发状况。结果试验组和对照组治愈率分别为76.9%和48.3%,复发率分别为23.1%和51.7%,试验组和对照组复发率比较,差异有统计学意义(P<0.05)。结论 5-氨基酮戊酸光动力疗法治疗尖锐湿疣疗效高,可显著降低复发率。

Objective To evaluate the effi cacy of topical 5-aminolevulinic acid photodynamic therapy in the treatment of condyloma acuminatum. Methods Fifty patients with condyloma were divided into 2 groups, the treatment group（26 cases） accepted ALA-PDT treatment, and the control group（29 cases） given liquid nitrogen cryotherapy. The therapeutic effect and recurrence rate were evaluated at 12 weeks after the last treatment. Results The cure rate of the treatment group and the control group were 76.9% and 48.3% respectively, and the recurrence rate of the treatment group and the control group were 23.1% and 51.7% respectively, the recurrence rate had statistically signifi cant difference（P〈0.05） between the two groups. Conclusion ALA-PDT in the treatment of condyloma has higher cure rate and lower recurrence rate.