乳腺癌MRI非形态学特征与C-erbB-2表达的相关性研究

Correlation on MRI non-morphological features and C-erbB-2 expression of breast cancer

目的探讨乳腺癌MRI非形态学特征(血流动力学、功能学)与C-erbB-2表达的相关性。材料与方法对77例手术证实的乳腺癌患者的MRI非形态学特征与C-erbB-2表达情况进行分析,统计病变时间-信号强度曲线、早期强化率及ADC值,应用t检验、χ2检验及Spearman秩相关分析其与C-erbB-2表达的相关性。结果乳腺癌时间-信号强度曲线、早期强化率与C-erbB-2表达无相关,ADC值与C-erbB-2表达呈负相关,C-erbB-2表达组间ADC值差异有统计学意义,应用ROC曲线分析,得到判断C-erbB-2表达的最佳ADC值诊断界值为0.988×10-3mm2/s。结论乳腺癌C-erbB-2表达与MRI血流动力学指标无相关性,与ADC值呈负相关。

Objective：To explore the correlations of MRI non-morphological features （hemodynamic performance and function characteristics） and C-erbB-2 of breast cancer. Materials and Methods：Seventy-seven patients diagnosed as breast cancers by pathologic examination were reviewed, analysis the MRI non- morphological features and the C-erbB-2 expression, to explore pathological changes of time-signal intensity curve, early intensive rate and ADC values, using t-test and chi-square test and Spearman rank correlation analysis with the correlation of C-erbB-2 expression. Results： The time-signal intensity curve of breast cancer, early intensive rate had no correlation with C-erbB-2 expression, ADC values had negative correlation with C-erbB-2 expression, ADC values differences between the groups of C-erbB-2 expression was statistically signiifcant, the best threshold of ADC value to judgment C-erbB-2 expression was 0.988×10-3mm2/s by ROC curve. Conclusions： C-erbB-2 expression had no correlation with MRI hemodynamic performance indicators, had negative correlation with ADC values.