转录因子叉头框Q1与肿瘤相关性的研究进展

Progress in research on the transcription factor forkhead box Q1 in relation to malignant tumors

转录因子叉头框Q1(forkhead box Q1,FOXQ1)是叉头框(forkhead box,FOX)超家族的成员之一,广泛存在于人体的多种组织和器官,参与胚胎干细胞和脊椎动物的发育过程。作为转录因子,FOXQ1蛋白通过作用于靶基因的启动子或与其他转录因子相互作用激活靶基因的转录,并从上皮-间质转化(epithelial-mesenchymal transition,EMT)和细胞信号转导等多方面影响肿瘤的发生、发展、侵袭和转移过程。鉴于FOXQ1与肿瘤具有明显相关性,其表达水平可作为某些肿瘤预后评估的指标,并有望成为肿瘤治疗的新靶点。本文通过综述最新文献,着重阐述了FOXQ1在肿瘤发生和发展过程中的作用及其可能的机制,以期为肿瘤治疗和研究提供一些参考。

The transcription factor forkhead box Q1 （FOXQ1）, a member of foxhead box superfamily, widely exists in human tissues and organs, and it is involved in development process of embryonic stem cells and vertebrate. As a transcription factor, FOXQ1 protein activates the transcription by acting on promoter of target genes or interacting with other transcription factors, and it affects initiation, progression, invasion and metastasis of tumor cells in many aspects such as epithelial-mesenchymal transition （EMT） and cellular signal transduction. According to the relationship between FOXQ1 and tumors, the expression level of FOXQ1 can be used as a prognostic index for patients with certain tumors, and FOXQ1 is expected to be a novel target for tumor therapy. This review focuses on the role of FOXQ1 in initiation and progression of certain tumors as well as its potential mechanism, aiming to provide the valuable reference for anticancer treatment and research.