microRNAs调控肝再生的研究现状

Research status on regulation of liver regeneration of microRNAs

原发性肝癌是世界上第五大常见的肿瘤,在我国发病率极高,发病率已达十万分之二十至三十,男女比例8∶1。有研究认为主要原因是大量饮酒及肝硬化。目前治疗的方法很多,如介入法、射频消融、手术切除部分肝叶、肝移植等。随着肝移植开展的不断深入,肝再生的调控机制研究也成为热点,大多关注其启动阶段的研究,对其终止阶段研究较少,研究发现microRNAs家族成员参与了肝再生的负调控过程,这一发现为肝再生的研究提供了新的方向。

Primary hepatic carcinoma （HCC） is one of the world＇ s 5 most common types of cancer,its morbidity is very high in our country,nowadays it can reach 20 to 30 per hundred thousand,and male patients are eight times than female patients.Some researchers think that the main reasons for HCC are heavy drinking and liver cirrhosis.There are many methods for treatment,such as intervention,radiofrequency ablation,surgical removal of part of hepatic lobe,liver transplantation and so on.With the development of liver transplantation,the mechanism of liver regeneration research becomes a hot spot.Most researchers focus on the start-up phase of the liver regeneration,research on its termination phase is less.Some study found that members of the family of microRNAs involved in the negative control regulation of liver regeneration,this discovery provided a new direction in the research of liver regeneration.