中心动脉压与颈动脉内膜中膜厚度和心肌肥厚的相关性

The Correlation Between Central Aortic Pressure and Carotid Intima-media Thickness,Myocardial Hypertrophy

目的探讨高血压患者中心动脉压(CAP)与颈动脉内膜中膜厚度、心肌肥厚的相关性。方法选取2009年1月至2011年10月新疆医科大学第一附属医院高血压科高血压患者314例,对患者进行肱踝脉搏波传导速度(BaPWV)、中心动脉压、颈动脉内膜中膜厚度、室壁厚度检测。按颈动脉内膜中膜厚度值将研究对象分为颈动脉内膜中膜厚度<0.9 mm组和颈动脉内膜中膜厚度≥0.9 mm组。按是否合并左心室肥厚将研究对象分为不伴左心室肥厚组和伴左心室肥厚组。分别对比两组间BaPWV、CSP(中心动脉收缩压)、CDP(中心动脉舒张压)、CPP(中心动脉脉压)、AP(增强压)、AIx(增强指数)等数值以探讨之间的相关性。结果 BaPWV、CSP、AP、AIx、CPP均与颈动脉内膜中膜厚度、左心室肥厚相关(P<0.05)。结论 BaPWV、CSP、AP、AIx、CPP可能与颈动脉内膜增厚和心肌肥厚有关。

Aim To investigate the relationship of central arterial pressure（ CAP） and carotid intima-media thickness,cardiac hypertrophy. Methods 314 cases of patients with hypertension from January 2009 to October 2011 were chosen in the First Affiliated Hospital of Xinjiang Medical University. Those patients were checked for ankle-brachial pulse wave velocity,central aortic pressure,carotid intima-media thickness,and wall thickness. The subjects were divided into carotid intima-media thickness 0. 9 mm group,and carotid intima-media thickness ≥0. 9mm group. Subjects were divided into group with left ventricular hyperthrophy and group without left ventricular hypertrophy. To explore the correlation,BaPWV（ pulse wave velocity）,CSP（ systolic blood pressure of central aortic pressure）,CDP（ diastolic blood pressure of central aortic pressure）,CPP（ pulse pressure of central aortic pressure）,AP（ augmentation pressure） were contrasted between the two groups. Results The BaPWV（ pulse wave velocity）,CSP（ systolic blood pressure of central aortic pressure）,AP（ augmentation pressure）,AIx（ augmentation index）,CPP（ pulse pressure or central aortic pressure） were associated with carotid intima-media thickness,left ventricular hypertrophy,and the statistical comparison was significant（ P〈0. 05）. Conclusions The BaPWV（ pulse wave velocity）,CSP（ central aortic systolic pressure）,AP（ increase pressure）,AIx（ augmentation index）,CPP（ central aortic pressure pulse pressure） may be associated with carotid intimal thickening and related cardiac hypertrophy.