低频重复经颅磁刺激治疗精神分裂症幻听症状疗效的Meta分析

Efficacy of Low-frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Schizophrenia Auditory Hallucinations: A Meta-Analysis

目的研究低频重复经颅磁刺激(rTMS)治疗精神分裂症幻听症状的疗效。方法计算机检索Pubmed、EMbase、Cochrane图书馆、CNKI、万方数据库、维普中文期刊数据库(VIP),收集1995-2014年2月关于rTMS治疗精神分裂症幻听症状的随机对照研究(RCTs)。主要研究指标为阳性与阴性症状量表(PANSS)的幻听评分及幻听评定量表(AHRS)。文献筛选、资料提取和方法学质量评价由两位研究者独立进行,以RevMan 5.1软件进行Meta分析。结果 17篇RCTs满足纳入标准,共包括786名受试者。Meta分析结果显示,两组之间的PANSS的幻听评分比较,均数差为-1.10,95%CI为[-1.65,-0.54],差异有统计学意义(Z=3.89,P=0.0001);两组之间的AHRS比较,均数差为-3.89,95%CI为[-5.72,-2.06],差异有统计学意义[Z=4.17,P<0.00001]。结论低频rTMS对精神分裂症的幻听症状有效。

To study the therapeutic effects of low -frequency repetitive transcranial magnetic stimulate （ rTMS） on hallu-cination in schizophrenia patients .Methods The randomized controlled trials （ RCTs） about hallucination of schizophrenia treated with rTMS from 1995 to February 2014 were searched in The Pubmed,EMbase,Cochrane Library,CNKI,Wanfang Data and VIP.Measure-ments included the Positive and Negative Symptoms Scales （ PANSS） for clinical symptom and the Auditory Hallucination Rating Scale （ AHRS） .Two reviewers independently screened the literatures ,extracted the data ,and evaluated the methodological quality .Meta-ana-lyses were conducted by Revman 5.1 software.Results The total 17 RCTs were included.Among the 786 patients involved.The results of meta-analyses showed that the hallucination score of PANSS was significantly different between the two groups [MD=-1.10,95%CI：（-1.65,-0.54）,Z=3.89,P=0.0001];The score of AHRS was significantly different between the two groups [MD=-3.89,95%CI：（-5.72,-2.06）,Z =4.17,P〈0.00001].Conclusion Low -frequency repetitive transcranial magnetic stimulate are effective for schizophrenia with hallucination symptoms .