褪黑素水平对抑郁症患者下丘脑-垂体-肾上腺轴功能的影响

The Influences of Melatonin on Activity of Hypothalamic-pituitary-adrenal Axis in Depression

目的探讨抑郁症患者褪黑素(MT)水平对下丘脑-垂体-肾上腺轴(HPA)功能的影响。方法对86例抑郁症患者,检测血清MT、促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、皮质醇(COR),并分析其相互关系。结果1以MT中位数(51.3ng/L)为切点,将所有抑郁症患者分为MT高值组(>51.3ng/L,n=43)与MT低值组(<51.3ng/L,n=43),前者血清CRH、ACTH、COR均显著低于后者(t=3.330,3.315,2.314;P<0.01,0.01,0.05);2血清MT水平与CRH、ACTH水平负相关(r=-0.414,-0.329;P<0.01,0.05)。结论褪黑素对抑郁症患者的HPA轴功能可能有一定的抑制作用。

Objective To study the effects of melatonin（MT） on activity of hypothalamic -pituitary-adrenal（HPA） axis in depression.Methods Major depression patients（n=86） were rolled for the study and assigned to be tested by MT ,corticotrophin releasing hormone（CRH）,adrenocorticotrophin hormone （ACTH）,cortisol（COR） and 17-items hamilton depression scale for analysis .Results Divided by the median of serum MT level （51.3ng/L）,the patients who had higher MT level （〉51.3ng/L） had significantly decreased level of CRH,ACTH,COR （t=3.330,3.315,2.314;P〈0.01,0.01,0.05） than those who had lower MT level（〈51.3ng/L,n=43）. The serum level of MT was markedly related with CRH （r=-0.414,P〈0.01） or ACTH（r=-0.329,P〈0.05）.Conclusion Melatonin may inhibit the activity of hypothalamic -pituitary-adrenal axis in patients with depression .