晚发性抑郁症患者血清神经元特异性烯醇化酶及与认知功能的关系

Serum Neuron-specific Enolase and Cognitive Dysfunction in the Late-onset Depressions

目的观察晚发性抑郁症(LOD)患者血清神经元特异性烯醇化酶(NSE)的变化情况并探讨其与认知功能的关系。方法分别检测35例晚发性抑郁症患者(LOD组)、35例老年健康者(对照组)血清NSE水平,以简易智能状态检查量表(MMSE)评定LOD患者认知功能,以17项汉密尔顿抑郁量表(HAMD)评定抑郁的严重程度。结果 1LOD组血清NSE水平显著高于对照组,差异有统计学意义(t=4.504,P<0.001);2LOD患者MMSE评分显著低于对照组,差异有统计学意义(t=-3.457,P<0.01);3LOD患者血清NSE水平与MMSE评分负相关(r=-0.388,P<0.05),MMSE评分与HAMD评分负相关(r=-0.413,P<0.05)。结论晚发性抑郁患者血清NSE增高,并与其认知功能的改变存在相关性。

Objective To study the relationship between neuron -specific enolase （ NSE） and cognitive dysfunction in the late -onset depression （ LOD） .Methods 35 cases of LOD patients and 35 cases of health elder controls were rolled into the study .Serum level of NSE and cognitive function were evaluated using a mini -mental state examination （ MMSE） .Results Serum levels of NSE were increased significantly in LOD group compared with controls （t=4.504,P〈0.001） meanwhile the scores of MMSE significantly decreased （t=-3.457,P〈0.01）.The level of NSE in LOD patients was significantly correlated with the scores of MMSE （r=-0.388,P〈0.05）, while the latter was significantly correlated with the score of 17-items Hamilton Depression Scale HAMD （r=-0.413,P〈0.05）.Con-clusion The results suggest that late -onset depressive patients have higher serum levels of NSE ,which shows a correlation with cogni-tive dysfunction .