神经干细胞移植治疗帕金森病21例

Treatment of Parkinson disease by implantation of neural stem cells into stratums(report of 21 cases)

目的观察神经干细胞移植治疗帕金森病患者的效果。方法选取2006年1月至2008年12月我院收治的帕金森病患者21例[男15例,女6例;平均年龄（57.23±9.13）岁]。患者均签署知情同意书,所有患者住院治疗。靶点定位于纹状体,注入神经干细胞0.25 ml,细胞数量为3×107个。结果 21例患者出院后随访6~49个月,与治疗前相比,治疗后21例患者统一帕金森病评定量表评分、Hoehn-Yahr量表评分、39项帕金森生存质量问卷评分明显降低（P〈0.01）,Schwab-England量表评分明显升高（P〈0.01）。结论神经干细胞移植可以在一定程度上改善帕金森病患者的临床症状,提高其生活质量。

Objective To observe the curative effect of neural stem cells （NSCs） implantation into stratums on Parkinson disease. Methods NSCs （dose, 0.25 ml containing 3x107 NSCs） were transplanted into the striatums in each of 21 patients with Parkinson disease （age range, 42-79 year; mean age, 57.33 years） treated in Navy General Hospital from January, 2006 to December, 2008, of whom, 15 were males and 6 females. The neural function and life quality in all the patients were assessed by Unified Parkinson＇s Disease Rating Scale （UPDRS）, Hoehn-Yahr Scale, Parkinson＇s Disease Questionaire （PDQ-39） and Schwab-England Scale before the transplantation and from 6 to 49 months （mean, 24.9 months） after the transplantation. Results The scores of UPDRS, the Hoehn-Yahr scale and PDQ-39 were significantly lower 6 months after the transplantation than those before the transplantation in the 21 patients （P〈0.01）. The scores of Schwab-England Scale was significantly higher 6 months after the transplantation than those before the transplantation in all the patients （P〈0.01）. Clinical symptoms such as tremor, rigidity, slow movement, unstable posture and so on were significantly improved after the transplantation in all the patients. Conclusions The clinical symptoms may be relieved and the life quality may be improved by the transplantation of NSCs into the striatums in the patients with Parkinson disease.