生长激素释放肽在功能性消化不良中的研究进展

Research progress of ghrelin on the functional dyspepsia

功能性消化不良(functional dyspepsia,FD)是一种常见的功能性胃肠道疾病,造成FD的病因目前尚未完全阐明。生长激素释放肽(Ghrelin)是一种主要由胃的内分泌细胞(X/A样细胞)分泌的脑肠肽。受体在体内广泛分布,具有调节生长激素分泌、摄食和能量平衡,影响神经内分泌及胃肠功能等多种生物学作用。越来越多的研究表明Ghrelin在FD中对于提高摄食量、产生饥饿感及促进胃排空方面有积极作用。目前,Ghrelin已成为研究FD的新热点。

Functional dyspepsia is a common functional gastrointestinal disease , however , the cause of functional dyspepsia has not been fully elucidated .Ghrelin is braingut petide , secreted by major endocrine cells of the stomach （ x/A like cells ） .Its recep-tor is widely distributed in the body .It has many kinds of biological effects , such as regulating growth hormone secretion , feeding and energy balance , affecting neuroendocrine and gastrointestinal function and so on .A growing number of studies have shown that Ghrelin in FD has a positive role in increasing the improvement of food intake and generating hunger , promoting gastric emptying .Ghrelin is a new hot spot in the research of FD .