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震惊反射系统在研究小鼠感觉运动门控功能中的应用 被引量:2

Application of Startle Response System in Study of Sensorimotor Gating of Mice
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摘要 感觉运动门控功能异常与多种精神疾病相关,前脉冲抑制是常用的测量感觉运动门控的重要行为学参数。该文介绍了用震惊反射系统测定C57BL/6J品系小鼠前脉冲抑制的实验方法,并用N-甲基-D-天冬氨酸受体非竞争拮抗剂MK-801(Dizocilpine,地卓西平)成功构建了药物诱发前脉冲抑制缺失的小鼠模型。 Dysfunction of sensorimotor gating is related to many kinds of psychiatric disorders. Prepulse inhibition, as a robust operational measure of sensorimotor gating, was tested in C57BL/6J mice using startle response system in this study. Furthermore, a mouse model of PPI disruption induced by MK-801, which is a noncompetitive antagonist of the N-methyl-D-aspartate receptor, was successfully established.
出处 《中国细胞生物学学报》 CAS CSCD 北大核心 2014年第7期956-962,共7页 Chinese Journal of Cell Biology
关键词 感觉运动门控 听震惊反射 前脉冲抑制 MK-801 sensorimotor gating acoustic startle reflex prepulse inhibition MK-801
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