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震惊反射系统在研究小鼠感觉运动门控功能中的应用 被引量：2

Application of Startle Response System in Study of Sensorimotor Gating of Mice
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摘要 感觉运动门控功能异常与多种精神疾病相关,前脉冲抑制是常用的测量感觉运动门控的重要行为学参数。该文介绍了用震惊反射系统测定C57BL/6J品系小鼠前脉冲抑制的实验方法,并用N-甲基-D-天冬氨酸受体非竞争拮抗剂MK-801(Dizocilpine,地卓西平)成功构建了药物诱发前脉冲抑制缺失的小鼠模型。 Dysfunction of sensorimotor gating is related to many kinds of psychiatric disorders. Prepulse inhibition, as a robust operational measure of sensorimotor gating, was tested in C57BL/6J mice using startle response system in this study. Furthermore, a mouse model of PPI disruption induced by MK-801, which is a noncompetitive antagonist of the N-methyl-D-aspartate receptor, was successfully established.
作者 王皓月 黄丹仪 李俊 吴文婷 应悦 王维刚 费俭
机构地区 同济大学生命科学与技术学院 上海南方模式生物研究中心
出处 《中国细胞生物学学报》 CAS CSCD 北大核心 2014年第7期956-962,共7页 Chinese Journal of Cell Biology
关键词 感觉运动门控 听震惊反射 前脉冲抑制 MK-801 sensorimotor gating acoustic startle reflex prepulse inhibition MK-801
分类号 Q42 [生物学—神经生物学]
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参考文献2

二级参考文献51

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共引文献13

同被引文献57

  • 1周洪霞,张连元,张田,田清友,胡永奇,董淑云,张宇新.MK801对大鼠肢体缺血/再灌注致脑组织发生细胞凋亡的影响[J].中国应用生理学杂志,2007,23(3):276-279. 被引量：2
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  • 10Lainiola M, Procaccini C, Linden AM. mGluR3 knockout mice show a working memory defect and an enhanced response to MK-801 in the T-and Y-maze cognitive tests [J]. Behavioural Brain Research, 2014, 266: 94- 103.

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二级引证文献7

中国细胞生物学学报
2014年 第7期

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