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抑制雄激素代谢和新生:去势抵抗型前列腺癌治疗的新靶点 被引量：4

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摘要 前列腺癌(PCa)经雄激素剥夺治疗后终将进展为临床难治的去势抵抗型前列腺癌(CRPC),其重要的机制之一就是人体内雄激素代谢途径的改变以及CRPC细胞内雄激素的新生使得PCa能够有效对抗去势后睾丸来源雄激素的大幅度减少。当前,针对雄激素代谢与新生过程中的关键酶开发新一代的靶向抑制剂已成为热点,为更有效地治疗CRPC提供了新的方法和手段。
作者 吴开杰 王彬 贺大林
机构地区 西安交通大学泌尿外科研究所 西安交通大学第一附属医院泌尿外科
出处 《现代泌尿外科杂志》 CAS 2014年第7期487-490,共4页 Journal of Modern Urology
基金 国家自然科学基金(No.81202014) 中央高校基本科研业务费专项资金(No.08143028)
关键词 前列腺癌 去势抵抗 雄激素代谢 雄激素新生 新药研发
分类号 R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献21

  • 1STANBROUGH M, BUBLEY GJ, ROSS K, et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer [J]. Cancer Res, 2006, 66(5) : 2815-2825.
  • 2CHANG KH, LI R, PAPARI-ZZREEI M, et al. Dihydrotestos- terone synthesis bypasses testosterone to drive castration-resist- ant prostate cancer [J]. Proc Natl Acad Sci U S A, 2011, 108 (33) : 13728-13733.
  • 3AKHTAR MK, KELLY SL, KADERBHAI MA. Cytochrome b(5) modulation of 17 { alpha} hydroxy]ase and 17-20 ]yase (CYP17) activities in steroidogenesis [J]. J Endocrinol, 2005, 187(2) : 267-274.
  • 4PONT A, WILLIAMS PL, AZHAR S, et al. Ketoconazole blocks testosterone synthesis [J]. Arch Intern Med, 1982, 142 (12): 2137-2140.
  • 5SMALL EJ, HALABI S, DAWSON NA, et al. Antiandrogen withdrawal alone or in combination with ketoconazole in andro- gen-independent prostate cancer patients: a phase Ⅲ trial (CAL- GB9583) [J]. J ClinOncol, 2004, 22(6): 1025-1033.
  • 6ATTARD G, REID AH, YAP TA, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hor- mone driven [J]. J Clin Oncol, 2008, 26(28): 4563-4571.
  • 7REID AH, ATTARD G, DANILA DC, et al. Significant and sustained antitumor activity in post-docetaxel, castration-resist- ant prostate cancer with the CYP17 inhibitor abiraterone acetate [J]. JClinOncol, 2010, 28(9): 1489-1495.
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二级参考文献28

  • 1杨念钦,王益鑫.激素非依赖性前列腺癌分子机制的研究现状[J].中华男科学杂志,2006,12(6):551-554. 被引量：4
  • 2宋海珠,陈龙邦.激素抵抗型前列腺癌的研究进展[J].中华男科学杂志,2007,13(1):57-60. 被引量：17
  • 3Mohler JL, Gregory CW, Ford OH 3rd, et al. The androgen axis in recurrent prostate cancer. Clin Cancer Res, 2004, 10(2) : 440-448.
  • 4Attard G, Reid AH, Yap TA, et al. Phase I clinical trial of a se- lective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol, 2008, 26(28) : 45634571.
  • 5Stanbrough M, Bubley GJ, Ross K, et al. Increased expression of genes converting adrenal androgens to testosterone in androgen- independent prostate cancer. Cancer Res, 2006, 66 ( 5 ) : 2815- 2825.
  • 6Locke JA, Wasan KM, Nelson CC, et al. Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A: Cholesterol acyltransferase (ACAT). Prostate, 2008, 68( 1): 20-33.
  • 7Auchus RJ. The backdoor pathway to dihydrotestostemne. Trends Endocfinol Metab, 2004, 15 (9) : 432-438.
  • 8Chang KH, Li R, Papari-Zareei M, et al. Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant pros- tate cancer. Proc Natl Acad Sci USA, 2011, 108(33) : 13728- 13733.
  • 9Geller J, Albert JD, Nachtsheim DA, et al. Comparison of pros- tatic cancer tissue dihydrotestosterone levels at the time of relapse following orchiectomy or estrogen therapy. J Urol, 1984, 152 (4) : 693-696.
  • 10Platz EA, Clinton SK, Giovannucci E. Association between plas- ma cholesterol and prostate cancer in the PSA era. Int J Cancer, 2008, 123(7): 1693-1698.

共引文献11

同被引文献24

引证文献4

二级引证文献22

现代泌尿外科杂志
2014年 第7期

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