PCT、IL-6及CRP在伴外科并发症的过敏性紫癜患儿血清中变化的意义

The changes of serum procalcitonin, interleukin-6 and C reactive protein in children with Henoch-Schonlein purpura combined with surgical complications

目的探讨伴腹部外科并发症的过敏性紫癜(HSP)患儿血清前降钙素(PCT)、白介素-6(IL-6)及C-反应蛋白(CRP)水平的动态变化。方法选择2010年1月至2013年6月期间住院的伴腹部外科并发症的HSP患儿48例,于入院第1、3、5天及出院前采集空腹静脉血,检测血清PCT、IL-6及CRP水平。结果 HSP患儿入院第1、3、5天血清PCT、IL-6水平以及入院第1、3天血清CRP水平均高于对照组,差异有统计学意义(P均<0.05)。手术组和非手术组HSP患儿,入院第1、3、5天以及出院前血清PCT、CRP和IL-6水平的差异有统计学意义(P均<0.01),均呈逐渐下降趋势。手术治疗患儿第3、5天的血清PCT、IL-6水平低于非手术治疗患儿,第5天血清CRP水平低于非手术治疗患儿,差异有统计学意义(P均<0.05)。患儿血清PCT水平与IL-6、CRP的水平均呈直线正相关(r=0.48、0.62,P均<0.01)。结论 PCT、IL-6及CRP水平变化可能与HSP伴发的腹部外科并发症的发生与感染因素关系密切,监测其变化有助于判断病情及指导治疗。

Objective To investigate the changes of serum procalcitonin （PCT）, interleukin-6 （IL-6） and C reactive protein （CRP） in children with Henoch-Sch？nlein purpura （HSP） combined with surgical complications. Methods From January 2010 to June 2013, 48 children with HSP combined surgical complications were enrolled, the fasting venous blood were obtained in day 1, 3, 5 of admission and before discharge. Meanwhile, 30 healthy children were selected as control. Results Compared with the control group, the levels of serum PCT and IL-6 in day 1, 3, 5 of admission, and the levels of serum CRP in day 1, 3 of admission were higher in children with HSP combined with surgical complications （all P〈0.01）. The differences of levels of serum PCT, CRP and IL-6 in day 1, 3, 5 of admission and before discharge were statistically signiifcant between surgical group and non-surgical group. All these indicators showed a gradual downward trend. Compared with surgical group, the levels of serum PCT and IL-6 in day 3, 5 of admission and serum CRP in day 5 of admission were signiifcantly lower in non-surgical group （P〈0.05）. There were positive linear correlations between the level of serum PCT and IL-6, and between the level of PCT and CRP （r=0.48, 0.62, P〈0.01）. Conclusions The changes of serum PCT, IL-6 and CRP may be associated with the occurrence of surgical complications in children with HSP, monitor these indicators may help to assess the condition and to guide the treatment.