乳腺癌组织中P27蛋白和血管内皮生长因子的表达及意义

Expression and significance of P27 protein and vascular endothelial growth factor in breast cancer

目的探讨乳腺癌组织中P27蛋白和血管内皮生长因子(VEGF)的表达意义,及其与乳腺癌病理类型的相关性。方法分析2010年5月至2013年9月接受手术治疗的60例乳腺癌患者(乳腺癌组织)的临床资料和病理标本,另选取30例正常乳腺组织标本作为对照(正常乳腺组织)。比较乳腺癌组织和正常乳腺组织中P27蛋白和VEGF的阳性表达率,以及P27蛋白和VEGF表达水平与病理类型的相关性。结果乳腺癌组织中VEGF的阳性表达率高于正常乳腺组织(P<0.01),而P27蛋白的阳性表达率明显低于正常乳腺组织(P<0.01)。不同病理类型标本中P27蛋白(P=0.76)和VEGF的阳性表达率差异无统计学意义(均P>0.05)。结论乳腺癌组织中VEGF水平显著高于正常乳腺组织,P27蛋白表达水平显著下降,且P27蛋白和VEGF的表达与乳腺癌病理分型无关。

Objective To investigate the expression and significance of VEGF and P27 protein in breast cancer, and the correlation between VEGF and P27 level and breast cancer pathological types. Methods Sixty specimens were selected from May 2010 to September 2013 in patients with breast cancer, meanwhile 30 normal breast tissue specimens were selected as control group. VEGF and P27 protein expression in breast cancer and normal breast tissue were compared, and the correlation between P27 protein expression together with VEGF and different pathological subtypes were analyzed. Results VEGF （ X2 = 33.951, P 〈 0. 01 ） expression rate was significantly higher in breast cancer tissue than that in normal breast tissue, but P27 protein （ Z2 = 17. 457, P 〈 0. 01 ） expression rate was significantly lower than that in normal breast tissue; no significant difference between different pathological types of specimens for P27 （ Z2 = 1. 866, P = O. 76） and VEGF （ Z2 = 1. 486, P = 0. 83 ） expression rate. Conclusion The level of VEGF in breast cancer tissues was significantly higher than that in normal breast tissue, P27 protein was significantly de- creased, VEGF and P27 expression did not associate with pathological subtypes.