热量限制联合心理引导及高压氧治疗对脑胶质母细胞瘤病人生存期的影响

Perspective research of the influence of caloric restriction combined with psychotherapy and chemotherapy associated by hybaroxia on the prognosis of patients suffered by glioblastoma multiforme

目的 在手术切除及放化疗基础上,探索对脑胶质母细胞瘤病人进行热量限制性饮食联合引导良好的心理状态以及与化疗同步的高压氧治疗,是否可以明显延长病人的术后生存期.方法 采用前瞻性、非随机、非双盲及对照实验方法,对象为2007年11月至2009年4月在北京天坛医院或北京天坛普华医院手术治疗的病人,共34例.所有病例均为肿瘤全切（90％以上）,分子病理学证实为脑胶质母细胞瘤.其中实验组11例,对照组23例.实验组的治疗是在手术及放化疗的基础上,进行热量限制性饮食、心理引导及与化疗同步的高压氧治疗.对照组仅进行手术及放化疗.结果 实验组病人生存期（38 ± 13）个月,对照组病人生存期（20±12）个月,两组比较差异有统计学意义（P＜0.05）.结论 热量限制性饮食联合心理引导及与化疗同步进行高压氧辅助治疗,可以明显延长脑胶质母细胞瘤病人的生存期.

Objective To explore the influence of caloric restrction combined with psychotherapy and chemotherapy associated by hybaroxia on the prognosis of patients with intracranial glioblastoma multiforme.Methods This was a perspective,nonrandom,no-double-blinded controlled study.All patients underwent total resection during November 2007 to April 2009 at Beijing Tiantan Hospital and Beijing Tiantan Puhua Hospital.All diagnoses were confirmed by molecule pathology.While 23 patients in control group underwent resections and radiochemotherapy,11 patients in experimental group were further treated by caloric restriction plus psychotherapy and chemotherapy-associated hybaroxia.The life spans were compared between two groups.Results The mean survival time of patients in experimental group was （38 ± 13） months versus （20 ± 12） months in control group.The survival time of patients in experimental group was significantly longer than that in control group （P ＜ 0.05）.Conclusion Caloric restriction plus psychotherapy and chemotherapy-associated hybaroxia can apparently prolong the life span of patients with glioblastoma multiforme.