通灌液保留灌肠治疗慢性溃疡性结肠炎随机平行对照研究

Retention Enema with TongGuan Solution Treat Chronic Ulcerative Colitis Randomized Parallel Group Study

[目的]观察通灌液保留灌肠治疗慢性溃疡性结肠炎疗效。[方法]使用随机平行对照方法,将96例门诊患者按病志号顺序简单随机分为两组。对照组48例柳氮磺胺吡啶2片,3次/d,饭前口服。治疗组48例通灌液(苦参30g,黄柏10g,白及15g,白矾10g,血余炭、穿心莲、青黛各15g,三七、儿茶、木香各10g),1剂/d,水煎100mL,早、晚各1次,灌肠。连续治疗4周为1疗程。观测临床症状、结肠黏膜性状、不良反应。连续治疗1疗程,判定疗效。[结果]治疗组临床缓解18例,有效28例,无效2例,总有效率95.83%。对照组临床缓解10例,有效30例,无效8例,总有效率83.33%。治疗组疗效优于对照组(P<0.05)。[结论]通灌液保留灌肠治疗慢性溃疡性结肠炎疗效显著,值得推广。

[Objective] To observe the therapeutic effects of retention enema with TongGuan solution on the treatment of chronic ulcerative colitis. [ Methods ] random parallel control method, 96 outpatients by randomly into two groups. The control group 48 cases of sulfasalazine tablets 2, 3 times / d, orally before meals. Treatment group, 48 cases through irrigation fluid （ Kushen 30g, Huangbai 10g, Baiji 15g, Baifan 10g, Xueyutan, Chuanxinlian, Qingdai each 15g, Sanqi, Ercha, Muxiang each 10g）, 1 dose / d, water fried 100mL, morning and evening, the 1st, enema. Continuous treatment for 4 weeks for a course of treatment. Observing clinical symptoms of adverse reactions. A continuous course of treatment to determine efficacy. [ Results ] The clinical remission in 18 cases, effective in 28 cases, 2 cases, the total efficiency of 95.83%. Clinical remission in 10 cases in the control group, 30 cases, 8 cases, the total efficiency of 83.33%. Treatment group than the control group （ P 〈0.05 ） . [ Conclusion ] Treating chronic ulcerative colitis （ dampheat syndrome ） by retention enema with the TongGuan solution can effectively improve symptoms, enhance the curative rate.