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阻塞性睡眠呼吸暂停低通气综合征患者血清网膜素水平的研究

The role of serum omentin levels in obstructive sleep apnea hypopnea syndrome patients
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摘要 目的探讨阻塞性睡眠呼吸暂停低通气综合征(Obstructive sleep apnea hypopnea syndrome,OSAHS)患者血清网膜素(Omentin)水平的变化及意义。方法选取80名经睡眠多导图监测的受试者,根据体质量指数和呼吸暂停低通气指数将其分为3组,对照组、超重非OSAHS组、超重OSAHS组,其中超重OSAHS组中有12名受试者进行了一晚经鼻持续气道正压通气(nasal continuous positive airway pressure,nCPAP)治疗。测定3组受试者以及12名经一晚nCPAP治疗患者的血清Omentin、空腹血糖、血脂。结果超重OSAHS组患者血清Omentin水平较超重非OSAHS组明显降低(P<0.05)。结论超重OSAHS组患者中Omentin水平下降,提示Omentin可能参与了OSAHS的发生。 Objective To explore the changes and significance of serum omentin levels in obstructive sleep apnea hyponea syndrome(OSAHS) patients. Methods Eighty subjects under polysomnography monitoring were divided into control group, overweight non- OSAHS group, overweight OSAHS group according to BMI and AHI. Twelve subjects in the overweight OSAHS group received one- night nasal continuous positive airway pressure (nCPAP) treatment. Then the levels of serum omentin, fasting blood glucose and blood lipids were determined in the three groups and the 12 subjects receiving nCPAP treatment. Results Serum omentin levels were significantly lower in overweight OSAHS patients than overweight non - OSAHS group (P 〈 0.05). Conclusion Serum omentin decrease in overweight OSAHS patients indicated omentin may be involved in the occurrence of OSAHS.
出处 《中国卫生检验杂志》 北大核心 2014年第14期2031-2033,共3页 Chinese Journal of Health Laboratory Technology
关键词 阻塞性睡眠呼吸暂停低通气综合征 网膜素 肥胖 Obstructive sleep apnea hypopnea syndrome (OSAHS) Omentin Obesity
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