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PDCD4和B7-H4在儿童视神经胶质瘤中的表达及临床意义

Expressions and clinical significance of PDCD4 and B7- H4 in optic gliomas in children
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摘要 目的:研究PDCD4和B7-H4在儿童视神经胶质瘤中的表达及临床意义。方法:采用免疫组织化学法对52例儿童视神经胶质瘤手术切除标本中PDCD4和B7-H4的表达进行检测,评估PDCD4和B7-H4的表达与儿童视神经胶质瘤临床病理因素的关系。结果:PDCD4在胶质瘤组织的阳性表达降低:52例胶质瘤组织中PDCD4表达阳性率随着肿瘤恶性程度增加呈降低趋势(P<0.01);B7-H4在胶质瘤组织的阳性表达增高:B7-H4在52例胶质瘤组织中阳性率随着肿瘤恶性程度增加显著增高(P<0.01);脑胶质瘤中PDCD4与B7-H4表达负相关(P<0.01)。结论:PDCD4和B7-H4与儿童视神经胶质瘤的恶性程度有关,对于儿童视神经胶质瘤的转移防治及预后具有一定的临床意义。 AIM： To study the expressions and clinical significance of PDCD4 and B7- H4 in optic gliomas in children.METHODS： We used immunohistochemistry to evaluate the expressions of PDCD4 and B7- H4 in specimens from 52 optic gliomas in children cases, and analyzed the correlation of PDCD4 and B7- H4 expression with clinicopathological factors children optic gliomas.RESULTS： PDCD4 expression reduced in optic glioma tissue： PDCD4 expression rate in 52 cases of optic glioma tissues decreasing was correlated with tumor malignancy increase（P〈0. 01）; B7- H4 positive expression increased in optic glioma tissue： B7- H4 expression rate in 52 cases of optic glioma tissues increasing was correlated with tumor malignancy increase（P〈0. 01）; PDCD4 expression was negatively correlated with B7- H4 expression in optic gliomas（P〈0. 01）.CONCLUSION： Expressions of PDCD4 and B7- H4 may be clinically relevant to tumor malignancy of optic gliomas in children and prevention of metastasis and prediction of prognosis.
作者 刘彦彤
机构地区 西安医学院基础部生物化学与分子生物学教研室
出处 《国际眼科杂志》 CAS 2014年第8期1391-1393,共3页 International Eye Science
基金 陕西省教育厅基金资助(No.2011JK0670)~~
关键词 儿童 视神经 胶质瘤 PDCD4 B7-H4 children optic gliomas PDCD4 B7-H4
分类号 R739.7 [医药卫生—肿瘤]
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参考文献14

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国际眼科杂志
2014年 第8期

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