角膜穿孔临床研究分析

Clinical research on corneal perforation

目的:研究角膜穿孔(corneal perforation,CP)患者的临床发病特点。方法:回顾性分析1995-07/2010-07福建医科大学附属第一医院住院确诊的CP患者72例72眼,分析其患者临床特点。结果:福建地区角膜溃疡穿孔发病率逐年上升,男女发病率比为17∶7,48岁为发病集中年龄,产业工人23例(32%),23例有明确外伤史,菌属鉴定结果:前两位为:真菌感染和棘阿米巴原虫感染。其中10例有糖皮质激素用药史。结论:外伤、真菌性、棘阿米巴角膜炎、蚕食性角膜炎等所致CP的原发病因多种多样,福建地区CP多发于中老年的男性,多数外伤为诱因,致病菌属以真菌感染为主。

AIM： To study the clinical characteristics of corneal perforation（CP）.METHODS： A retrospective analysis in July 1995 to July2010 the First Affiliated Hospital of Fujian Medical University diagnosed CP 72 patients（ 72 eyes）,clinical characteristics of all the patients were analyzed.RESULTS： The incidence of corneal ulcer perforation rised year by year,the morbidity of male and female was17∶ 7, the onset age focused on 48 years old. Of 23 industrial workers（ 32%） with clear history of trauma,pathogeny identification results： top two： fungal infection and Acanthamoeba keratitis. A using history of glucocorticoid was found in 10 cases.CONCLUSION： There are plenty of primary causes of CP such as traumas, fungal infection, Acanthamoeba keratitis,eroded keratitis,etc. CP happens in middle-aged males in Fujian province, most traumas are the causes,the main pathogenic bacteria is fungal infection.