脂质体、免疫刺激复合物和壳聚糖作为黏膜免疫载体的研究现状

Liposome, Immune Stimulating Complexes and Chitosan as the Research Status of Mucosal Immune Carrier

查阅国内外文献,采用整理归纳、引用和分析的方法,概述了鼻黏膜免疫载体材料脂质体、免疫刺激复合物和壳聚糖的生物学特性及其在气溶胶疫苗领域的应用。脂质体、免疫刺激复合物和壳聚糖作为气溶胶疫苗鼻黏膜免疫的载体,能够增强疫苗的免疫原性,提高机体的体液免疫和细胞免疫水平,因此,可作为疫苗抗原激发特异免疫应答的生物材料。

The biological characteristics and application in the field of aerosol vaccine of liposome, immune stim-ulating complexes and chitosan as the nasal mucosal immune carrier materials were summarized. The liposome, im-mune stimulating complexes and chitosan as vaccine carrier can enhance the immunogenicity of vaccine and the humoral and cellular immune level. Therefore, liposome, immune stimulating complexes and chitosan can be used as vaccine antigen to stimulate specific immune response of biological materials.