宫颈上皮内瘤变治疗后高危型HPV的清除趋势

Clearance Tendency of High Risk HPV After Treatment of Cervical Intraepithelial Neoplasia

目的：探讨宫颈鳞状上皮内瘤变（CIN）治疗后高危型人乳头瘤病毒（HR-HPV）清除趋势.方法：对2008年10月1日～2009年12月30日在新疆自治区人民医院用第二代杂交捕获（Hybird Capture-2,HC2）法检测HR-HPV阳性,在阴道镜下活检诊断为CIN的90例患者进行高频电波刀宫颈环状电圈切除术（The loop electrosurgical excision procedure,LEEP）或者冷刀锥切术（cold-knife conization CKC）,术后6、12、18、24个月分别行HR-HPV检测进行随访.对治疗后HR-HPV的清除趋势进行回顾性分析.结果：1.CIN病变治疗后未复发及残留者术后6、12、18、24个月HR-HPV清除率分别为78.20％、89.74％、96.10％、98.72％.CIN Ⅰ、CINⅡ、CINⅢ各组锥切术后HR-HPV清除率之间无统计学差异（P＞0.873）.结论：1.CIN治疗后6个月HR-HPV可大部分消退,术后2年基本完全消退.CIN治疗后HR-HPV清除率与病变级别之间无显著相关性.

Objective： To approach the clearance tendency of high risk HPV after treatment of cervical intraep, ithelial neoplasm （CIN） Methods： A retrospective study was conducted on 90 women who underwent LEEP or CKC for cervical intraepithelial neoplasm in Xinjiang General Hospital from august 2008 to December 2009.For all patient with HR-HPV positive hybrid capture Ⅱ method was used to detect viral load of HR-HPV respectively 6,12,18,24 months after treatment. Results：l. Among those who were high-risk HPV infected before eonization of cervix and there was no residua or recurrence after treatment, the clearance rate of high-risk HPV in CINwas78.20% ,89.74%, 96.10%,98.72% after treatment 6, 12, 18 and 24months, respectively. There was no significant difference in persis- tent masculine of HR-HPV among biopsy histology CIN Ⅰ,CIN Ⅱ and CIN Ⅲ .Conclusion： 1.HR-HPV could subtotal cleared 6 months after conization, and could foundational completely cleared in 2years,