舒必利与氟西汀治疗轻、中度抑郁的对照研究

A compared study of sulpiride and fluoxetine in the treatment of patients with mild to Moderate depression

目的探讨舒必利对心境障碍轻、中度抑郁发作患者的治疗效果。方法将65例门诊和住院心境障碍轻、中度抑郁发作患者随机分为研究组和对照组,分别服用舒必利和氟西汀,研究组33例,对照组32例。应用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)、Bech-Rafaelsen躁狂量表(BRMS)评定疗效和躁狂转换风险,应用不良反应量表(TESS)、糖脂代谢生化指标和体重指数评定不良事件。结果 HAMD-17和HAMA评分同组比较,研究组治疗2周与治疗前比较差异有显著性,两组治疗4周、8周、12周与治疗前比较差异均有显著性;BRMS评分治疗8周、12周与治疗前比较差异有显著性;两组组间治疗前比较差异无显著性,治疗2周HAMD、HAMA评分比较差异有显著性;治疗8周、12周BRMS评分两组间及对照组与治疗前比较差异均有显著性。TESS统计两组不良事件相当。结论舒必利对心境障碍轻、中度抑郁发作有较好的治疗效果,起效快,安全性好,转躁风险小。

Objective To investigate the clinical efficacy of sulpiride in the treatment of mood disorder ’ s patients with mild to moderate depression. Method Divided 65 cases mood disorder’s patents with mild to moderate depres-sion of outpatients and inpatients into study group and control group according to the treatment sequence by random-ly,respectively took sulpiride and fluoxetine,study group 33 cases,control group 32 cases. Applied the Hamilton De-pression Scale（HAMD）,Hamilton Anxiety Scale（HAMA）,Bech-Rafaelsen Mania Rating Scale（BRMS） to assess the efficacy and manic conversion risk. To evaluate the adverse events with The Treatment Emergent Symptom Scale （TESS）,glucose and lipid metabolism and biochemical index and body mass index. Result HAMD-17 and HAMA scores compared between the two groups,study group for 2 weeks compared with before treatment had statistical sig-nificance,the scores after treated 4 weeks,8 weeks,12 weeks compared with before treatment there all had statistical significance. The BRMS scores for 8 weeks,12 weeks compared with before treatment had statistical significance,be-tween two groups before treatment showed no statistical significance. In the treatment of 2 weeks HAMD,HAMA score was statistically significant. The BRMS score between the two groups and for 8 weeks,12 weeks compared with before treatment in the control group all had statistical significance. TESS statistics the adverse events of two groups is quite. Conclusion Sulpiride in the treatment of mood disorder’s patients with mild to moderate depression has a better effect,good security,less mania conversion.