Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides

Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides

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摘要 In this paper, an efficient synthesis of 5-alkynyl-1,2,3-triazoles through a one-pot aerobic oxidative coupling reaction of various alkynes and azides has been developed. Further derivatization of 5-alkynyl-1,2,3-triazoles readily yielded 5-carbonyl-1,2,3-triazoles, 5-carboxylic-1,2,3-triazole, 5-hydroxyalkyl-1,2,3-triazoles and 5-quinoxaline-1,2,3-triazole, which provided an entry into structurally diverse 5-functionalized-1,2,3-triazoles. In this paper, an efficient synthesis of 5-alkynyl-1,2,3-triazoles through a one-pot aerobic oxidative coupling reaction of various alkynes and azides has been developed. Further derivatization of 5-alkynyl-1,2,3-triazoles readily yielded 5-carbonyl-1,2,3-triazoles, 5-carboxylic-1,2,3-triazole, 5-hydroxyalkyl-1,2,3-triazoles and 5-quinoxaline-1,2,3-triazole, which provided an entry into structurally diverse 5-functionalized-1,2,3-triazoles.

作者 Ling-Jun Li Yu-Qin Zhang Yang Zhang An-Lian Zhu Gui-Sheng Zhang

机构地区 School of Chemistry and Chemical Engineering

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第8期1161-1164,共4页 中国化学快报（英文版）

基金 the NSFC (Nos. 21172058, 20802017) HASTIT (No. 2012HASTIT10) PCSIRT (No. IRT1061) Key Technologies R & D Program of Henan Province (No. 112102310319) for financial support

关键词 ALKYNE AZIDE 1 2 3-TRIAZOLE Copper catalysis Alkyne Azide 1,2,3-Triazole Copper catalysis

分类号 O621.3 [理学—有机化学]

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Chinese Chemical Letters

2014年第8期

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Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides

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