子宫内膜异位症与抗碳酸酐酶抗体的关系

The relation of endometriosis and anticarbonic anhydrase.

目的 :探讨抗碳酸酐酶Ⅰ、Ⅱ抗体与子宫内膜异位症的关系。方法 :应用酶联免疫吸附 (ELISA)法分别检测内异症 32例、其他妇科疾病 (妇科组 ) 2 0例及正常妇女 12例血清抗碳酸酐酶抗体水平。结果 :(1)内异症患者血清抗碳酸酐酶Ⅰ、Ⅱ抗体阳性率(87.5 %、5 3.1% )高于妇科组 (2 5 %、15 % ) ,两组差异有显著性 (P <0 .0 1) ;(2 )内异症患者血清抗碳酸酐酶Ⅰ、Ⅱ抗体阳性率明显高于正常妇女组 (0 %、0 % ) ,两组差异有显著性 (P<0 .0 1) ;(3)妇科组及正常妇女组血清抗碳酸酐酶Ⅰ、Ⅱ抗体阳性率较低 ,两组差异无显著性 (P >0 .0 5 )。结论

Objective:To investigate the possibility of carbonic anhydrase (CA) level in diagnosing endometriosis.Methods:Antibody levels to human CA Ⅰ,Ⅱ in venous serum of32 patients with endometriosis,20 patients with other gynecologic disorders,and 12 normal women were measured by enzyme linked immunoassay (ELISA).Results: (1) The positive rates of CA Ⅰ and CA Ⅱ in patients with endometriosis were 87.5% and 53.1% respectively,which were significantly higher than those in patients with other gynecologic disorders (25% and 15%,P<0.01).(2)None of the normal women showed a positive reactivity to CAⅠ or CA Ⅱ.The positive rate of either CA Ⅰor CA Ⅱ in patients with endometriosis was significantly higher than that of normal women (P<0.01).(3)There was no significant difference (P>0.05) in CA Ⅰ and Ⅱ positive rates between normal women and patients with other gynecologic disorders. Conclusions:The level of autoantibody anainst CA may play an importmant role in the diagnosis and pathogenesis of endometrosis.