摘要
心肌兴奋-收缩偶联(ECC)是心脏电活动转换成机械收缩的过程,Ca2+释放通道(RyR2)在ECC中起核心作用。Ca2+和Na+转运参与ECC的全过程。Ca2+转运蛋白和细胞内激酶与心力衰竭的发生发展密切相关,Ca2+转运的改变常发生在心功能衰竭之前。Ca2+转运与Na+转运相互影响,细胞内Na+转运因细胞内Na+浓度和晚钠电流增加而受到干扰,舒张期Ca2+持续增加导致舒张功能障碍,并诱导心律失常。
Excitation-contraction coupling is the process by which the cardiomyocyte translates electrical excitation into mechanical contraction. The RyR2 plays a central role in the process. Ca^2＋ -handling and Na ^＋ -handling participate the whole process of excitation-contraction coupling. Alterations in Ca^2＋ -handling proteins and intracellular kinases are involved in the pathogenesis of heart failure. Changes in Ca^2＋ -handling often precede the depression of myocardial function. Intracellular Ca^2＋ -handling is closely coupled with intracellular Na^＋-handling. Intracellular Na^＋ -handling is disturbed with elevated intracellular Na^＋ -concentration and increased late INa. Diastolic Ca^2＋ can consecutively increase contributing to diastolic dysfunction and heart failure as well as arrhythmias.
出处
《基础医学与临床》
CSCD
北大核心
2014年第8期1129-1132,共4页
Basic and Clinical Medicine
基金
国家自然科学基金(81060013)
江西省自然科学基金(2010GZY0254)
关键词
兴奋-收缩偶联
钙
钙调蛋白依赖性蛋白激酶
钙转运
钠转运
excitation-contraction coupling
calcium/calmodulin-dependent protein kinase Ⅱ
Ca^2＋ -handling
Na^＋ -handling
