表观遗传修饰在氧化-抗氧化平衡调控中的改变及作用

Function of Epigenetic Changes in the Balance of Oxidative and An-tioxidant

机体氧化-抗氧化平衡对维持正常的生物学功能起着重要作用，外源刺激会打破该平衡，导致体内ROS的过量蓄积并诱导多种疾病的发生。表观遗传修饰通过影响ROS产生、清除及氧化还原平衡调控通路中关键分子的表达，从多个方面参与机体氧化-抗氧化平衡的调控，并在氧化应激相关疾病的发生发展中起着重要的作用。探讨表观遗传修饰在氧化-抗氧化平衡调控中的改变及其作用，为阐述外源刺激诱导机体氧化-抗氧化失衡及疾病发生的机制拓展了新的方向。

The balance between oxidative and antioxidant plays an important role in the maintenance of normally biological functions.Exogenous stimuli will break the balance , which leads to excessive accumulation of ROS and induce a variety of disease.Epigenetics make a contribution to the development of oxidative stress-related disease through involving in regulation of balance between oxidative and antioxidant.The expression of key molecules which are very important in generation and removement of ROS would be regulated by Epigenetics , which further disturb to the balance.Investigating the role of epigenetic modifications in the balance of oxidative and antioxidant provide a new direction to explain the mechanisms of disease caused by disturbing the balance .