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G蛋白偶联雌激素受体在雌激素相关肿瘤发生中的作用 被引量：10

Effect of G protein-coupled estrogen receptor on the occurrence and development of estrogen related cancer
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摘要 在经典的雌激素核受体α和β之外,雌激素或雌激素样物质也可以经过膜受体,即G蛋白偶联雌激素受体(GPER)发挥功能。G蛋白偶联雌激素受体是雌激素非基因通路信号转导过程的重要介导因子,在雌激素相关肿瘤细胞的发生和治疗中具有重要的意义。现针对G蛋白偶联雌激素受体在雌激素相关肿瘤细胞中介导的效应及有关机制的研究进展进行综述。 Estrogen or estrogenic substances can act via not only typical estrogen receptor aand β but also G protein-coupled estrogen receptor （ GPER ）. GPER is a crucial factor which can play an essential part in the non-genomic transduction pathway through which estrogen realizes its cellular functions, especially in the occurrence and treatment of estrogen related cancer. Hereis a brief review concerning the current advancements on the role of GPER in estrogen related cancer.
作者 赵丕文 David Yue-Wei Lee 陶仕英 陈梦 牛建昭
机构地区 北京中医药大学基础医学院 Mclean Hospital (Harvard Medical School)
出处 《中国药理学通报》 CAS CSCD 北大核心 2014年第8期1037-1041,共5页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 81273887) 高等学校创新引智计划(No B07007) 北京中医药大学自主科研课题(No JYBZZ-JS014)
关键词 G蛋白偶联雌激素受体 G蛋白偶联受体30 雌激素受体 肿瘤 雌激素 植物雌激素 乳腺癌 G protein-coupled estrogen receptor G-protein-coupled receptor 30 estrogen receptor cancer estrogen phy-toestrogen breast cancer
分类号 R-05 [医药卫生]
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参考文献42

  • 1Edwards D P. Regulation of signal transduction pathways by estrogen and progesterone[J]. Annu Rev Physiol, 2005,67:335-76.
  • 2Green S, Walter P, Kumar V, et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A[J]. Nature, 1986,320(6058):134-9.
  • 3Greene G L,Gilna P,Waterfield M, et al. Sequence and expression of human estrogen receptor complementary DNA[J]. Science, 1986,231(4742):1150-4.
  • 4Kuiper G G, Enmark E, Pelto-Huikko M, et al. Cloning of a novel receptor expressed in rat prostate and ovary[J]. Proc Natl Acad Sci USA, 1996,93(12):5925-30.
  • 5Moriarty K, Kim K H, Bender J R. Minireview: estrogen receptor-mediated rapid signaling[J]. Endocrinology, 2006,147(12):5557-63.
  • 6Byer S J, Eckert J M, Brossier N M, et al. Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner[J]. Neuro Oncol, 2011,13(1): 28-41.
  • 7Revankar C M, Cimino D F, Sklar L A, et al. A transmembrane intracellular estrogen receptor mediates rapid cell signaling[J]. Science, 2005,307(5715):1625-30.
  • 8Ariazi E A, Kraus R J,Farrell M L, et al. Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway[J]. Mol Cancer Res, 2007,5(1):71-85.
  • 9赵丕文,牛建昭,王继峰,郝庆秀,于杰,孙丽萍,黄春芳,陶仕英.丹参酮ⅡA抗乳腺癌细胞增殖作用研究[J].中国药理学通报,2010,26(7):903-906. 被引量：26
  • 10O'Dowd B F, Nguyen T, Marchese A, et al. Discovery of three novel G-protein-coupled receptor genes[J]. Genomics, 1998,47(2):310-3.

二级参考文献33

  • 1赵丕文,王大伟,王玲巧,牛建昭,王继峰.用小鼠子宫增重法筛选淫羊藿等10种中药雌激素样作用的实验研究[J].北京中医药大学学报,2006,29(10):686-689. 被引量：100
  • 2孟庆书,何平,朱晓燕,倪鑫.植物雌激素的作用机制[J].生命的化学,2007,27(2):141-143. 被引量：22
  • 3赵丕文,牛建昭,王继峰,王玲巧.异补骨脂素和蜕皮甾酮对人乳腺癌T47D细胞增殖及ER亚型表达的影响[J].北京中医药大学学报,2007,30(4):242-245. 被引量：26
  • 4Takeshi USUI. Pharmaceutical prospects of phytoextrogens [ J ]. Endoc J,2006,53 ( 1 ) :7 - 20.
  • 5Sathyamoorthy N, Wang TT, Phang, J M. Stimulation of pS2 expression by diet-derived compounds[ J]. Cancer Res, 1994,54(4) :957 -61.
  • 6Stossi F, Barnett D H, Frasor J, et al. Transcriptional profiling of estrogen-regulated gone expression via estrogen receptor(ER)α or ERβ in human osteosarcoma cells: distinct and common target genes for these receptors [ J ]. Endocrinol, 2004,145 ( 7 ) : 3473 - 86.
  • 7Cheung C P, Yu S, Wong K B, et al. Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues [ J ]. J Clin Endocrinol Metab, 2005,90 ( 3 ) : 1830 - 44.
  • 8Gaillard S, Dwyer M A, McDonnell D P, et al. Definition of the molecular basis for estrogen receptor-related receptor-α-cofactor interactions [ J ]. Mol Endocrinol, 2007,21 ( 1 ) :62 - 76.
  • 9Greschik H, Flaig R, Renaud J P, et al. Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestral or 4-hydroxytamoxifen and determinants of selectivity [ J ]. J Biol Chem,2004,279 (32) :33639 - 46.
  • 10Okada H, Tokunaga T, Liu X, et al. Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma [ J ]. Environ Health Perspect,2008,116( 1 ) :32 -8.

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中国药理学通报
2014年 第8期

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