摘要
骨关节炎是在复杂的生物学和力学因素共同作用下,软骨细胞、细胞外基质、软骨下骨三者合成与降解失衡的一种慢性、进行性疾病,其病因和病理机制目前尚未完全明确,但基质金属蛋白酶-13(MMP-13)对Ⅱ型胶原所组成三螺旋结构的降解和破坏被认为是OA发生发展的关键环节,MMP-13抑制剂的研究将会为OA的治疗提供新的思路和方法。
Osteoarthritis (OA) is a complex chronic progressive disease attacked by biological and mechanical factors and a result from the anabolic and catabolic imbalance in chondrocyte, subchondral bone and extracellular matrix (ECM). Eti-ology and pathological of OA are not yet entirely clear. The degradation and destruction of collagen Ⅱcaused by matrix metal- loproteinase -13 (MMP-13) is considered the core factor in the occurrence and development of OA. The research of MMP-13 inhibitor provide ideas and methods for the treatment of OA. In this atticle, the role and determination of MMP-13 in OA and the clawlnnrnant prospect of MMP-13 inhibitor in the treatment of OA.research progress were reviewed.
出处
《中国骨伤》
CAS
2014年第7期617-620,共4页
China Journal of Orthopaedics and Traumatology
基金
2013浙江省科技厅第二批重大科技专项重大社会发展项目(编号:2012c13017-2)~~
关键词
h基质金属蛋白酶-13
骨关节炎
软骨
关节
胶原
综述文献
Matrix metalloproteinase-13
Osteoarthritis
Cartilage, articular
Collagen
Review literature