基质金属蛋白酶-13的测定在骨关节炎中作用的研究进展

Research on application of determination of MMP-13 in osteoarthritis

骨关节炎是在复杂的生物学和力学因素共同作用下,软骨细胞、细胞外基质、软骨下骨三者合成与降解失衡的一种慢性、进行性疾病,其病因和病理机制目前尚未完全明确,但基质金属蛋白酶-13(MMP-13)对Ⅱ型胶原所组成三螺旋结构的降解和破坏被认为是OA发生发展的关键环节,MMP-13抑制剂的研究将会为OA的治疗提供新的思路和方法。

Osteoarthritis （OA） is a complex chronic progressive disease attacked by biological and mechanical factors and a result from the anabolic and catabolic imbalance in chondrocyte, subchondral bone and extracellular matrix （ECM）. Eti-ology and pathological of OA are not yet entirely clear. The degradation and destruction of collagen Ⅱcaused by matrix metal- loproteinase -13 （MMP-13） is considered the core factor in the occurrence and development of OA. The research of MMP-13 inhibitor provide ideas and methods for the treatment of OA. In this atticle, the role and determination of MMP-13 in OA and the clawlnnrnant prospect of MMP-13 inhibitor in the treatment of OA.research progress were reviewed.