小RNA病毒3′非编码区结构与功能的研究进展

Structure and Function of 3′-Untranslated Region in Picornavirus

小RNA病毒基因组的两侧分别为5′非编码区(UTR)和3′UTR。研究表明:5′/3′UTR能形成复杂的RNA结构,如颈-环结构、三叶草结构和假结体结构等,在病毒的复制或翻译过程中发挥重要调节作用。本文即对近10年来有关小RNA病毒3′UTR的结构与功能研究方面的进展情况进行综述。

Both sides of the picornavirus genome have 5′-untranslated region（5′UTR）and 3′-untranslated region（3′UTR）.This study demontrated that both the 5′-and 3′-UTR can form complex structures,such as stem-loop,clover and pseudoknot structure,These structures play an important role in the regulaton of the replication and translation of the viruses.This article reviewed the progress of research on the structure and function of picornavirus′3′-UTR over recent years.