鼻内镜脑脊液鼻漏修补术后颅内感染临床分析

Clinical analysis on intracranial infection after nasal endoscopic repair surgery for cerebrospinal fluid rhinorrhea

共135例术后并发脑脊液鼻漏患者中3例发生颅内感染,分别为毛霉菌感染(1例)、脑脓肿(1例)和细菌感染(1例)。经感染灶清除术辅助抗真菌药物或抗生素治疗,随访2年,2例脑脊液鼻漏或颅内感染未复发、1例因多脏器衰竭死亡。鼻内镜脑脊液鼻漏修补术后发生颅内并发症罕见,需要相关科室协作共同治疗。

From June 2005 to October 2012,there were 135 cases with cerebrospinal fluid （CSF）rhinorrhea admitted in our hospital who underwent nasal endoscopic repair surgery,and intracranial infection happened in 3 cases after surgery,including intracranial mucormycosis in one case,brain abscess in one case and bacterial infection in one case.These 3 cases underwent surgery to clear up the focus of infection,supplemented by antifungal drugs or antibiotic therapy.Case 1 and Case 2 were followed up for 2 years without CSF rhinorrhea or intracranial infection; Case 3 died due to multiple organ failure.The intracranial complications after nasal endoscopic surgery for repairing CSF leakage are rare and need combined treatment of relevant departments.