COMT Val158Met基因多态性与精神分裂症发病风险的Meta分析

COMT Val158Met Gene Polymorphisms and Schizophrenia Susceptibility: A Meta Analysis

目的:探讨COMTVal158Met基因多态性与精神分裂症患病风险的相关性。方法:在PubMed、CNKI、CBM、EMBASE、MEDLINE和万方数据库中用计算机检索相关文献,运用Meta分析方法对纳入文献进行综合定量及亚组分析。计算合并相对比值比(OR)和95%可信区间(95%CI),使用Review Manager 5.1软件进行分析。结果:入选文献17篇,包括病例组4935例和对照组4282例。COMTVal158Met基因多态性与精神分裂症并无相关性(杂合子比较,P=0.07,I2=1%;隐形遗传模式比较,P=0.11,I2=0%)。亚组分析中,无论是高加索人群还是亚洲人群,COMTVal158Met基因多态性与精神分裂症发病风险无统计学依据(P>0.05)。结论:COMTVal158Met基因多态性与精神分裂症患病风险可能无相关性。

Background： To evaluate the correlation of COMT Val158Met gene with susceptibility to schizophrenia. Methods： A meta-analysis was performed by searching the published literatures in PubMed, CNKI, CBM, EMBASE, MEDLINE and Wanfang databases. Overall and subgroup analyses were performed. Odds ratio （OR） and 95% confidence interval （CI） were used to evaluate the associations between COMT Val158Met polymorphisms and schizophrenia risk. Statistical analysis was performed with Review Manager 5.1. Results： Seventeen studies addressing COMT Val158Met polymorphisms were analyzed among a total of 4 935 schizophrenic cases and 4 282 controls. There was no evidence that the COMT Val158Met polymorphism was associated with an increased schizophrenia risk （P〉0.05） in over all populations （heterozygote comparison, P= 0.07, I2=1%; recessive model comparison, P=0.11, I2=0%）. In subgroup analysis based on ethnic groups, no associations was found in Caucasus and Asians （P〉0.05）. Conclusion： It is likely that the COMT Val158Met gene polymorphism does not confer susceptibility to schizophrenia.