银杏叶提取物影响急性脑梗死患者血小板聚集率的研究

Study of the influence of Ginkgo biloba extract on platelet aggregation of the patients with acute cerebral infarction

目的 探讨银杏叶提取物对急性脑梗死患者血小板聚集率的影响.方法 选取急性脑梗死患者102例,按数字表法随机分为观察组与对照组,每组51例.对照组患者给予常规药物治疗,观察组组患者在对照组的基础上给予银杏叶提取物药物治疗.结果 两组患者治疗后ADP、AA和PAF诱导的血小板聚集率分别为（65.1±8.1）％、（71.2±3.6）％、（30.1±5.2）％、（39.8±5.8）％、（42.1±6.3）％、（49.6±6.1）％均显著低于治疗前的（78.1±9.2）％、（77.6±9.0）％、（57.1±8.2）％、（56.8±8.4）％、（62.4±8.6）％、（61.9±8.3）％,差异均有统计学意义（均P ＜0.05）.观察组患者治疗后ADP诱导的血小板聚集率为（65.1±8.1）％,显著低于对照组（t=5.732,P＜0.05）;观察组患者治疗后AA诱导的血小板聚集率为（30.1±5.2）％,显著低于对照组（t=6.897,P＜0.05）;观察组患者治疗后PAF诱导的血小板聚集率为（42.1±6.3）％,显著低于对照组（t=6.013,P＜0.05）.两组患者治疗后神经功能缺损评分分别为（5.98±1.09）分、（7.11±1.56）分,显著低于治疗前的（12.98 ±2.09）分、（11.75 ±1.74）分,差异均有统计学意义（均P ＜0.05）;观察组患者治疗后的评分为（5.98±1.09）分,显著低于对照组的（7.11±1.56）分（t=5.469,P＜0.05）.结论 银杏叶提取物可显著降低急性脑梗死患者的血小板聚集率,值得在临床中推广应用.

Objective To discuss the influence of Ginkgo biloba extract on platelet aggregation of the patients with acute cerebral infarction.Methods 102 patients with acute cerebral infarction were selected and randomly divided into the control group and the observation group,each group had 51cases.The patients of the control group were given the conventional drug therapy,while the observation group were given the Ginkgo biloba extract treatment on the basis of the treatment of the control group.Results The platelet aggregation of the two groups after treatment made significant difference compared with that before treatment（P ＜ 0.05）.The platelet aggregation caused by ADP was （65.1 ± 8.1） ％ and was obviously lower than that of the control group （t =5.732,P ＜ 0.05）.The platelet aggregation caused by AA was （30.1 ± 5.2） ％ and was obviously lower than that of the control group （t =6.897,P ＜0.05）.The platelet aggregation caused by PAF was （42.1 ± 6.3） ％ and was obviously lower than that of the control group （t =6.013,P ＜ 0.05）.The neurological function of the two groups after treatment made significant difference compared with that before treatment （P ＜ 0.05）.The socres of the observation groupafter treatment was （5.98 ±1.09）,which was obviously lower than that of the control group （t =5.469,P ＜ 0.05）.Conclusion Ginkgo biloba extract could significantly reduce the platelet aggregation of the patients with acute cerebral infarction and deserved promotion.