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酒精滥用的生物标志物及研究进展 被引量:3

Research Progress in Biomarkers of Alcohol Abuse
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摘要 目的:介绍近年来在酒精滥用生物标志物方面的若干研究进展。方法:对近年相关文献进行复习。结果:酒精滥用的生物标志物可归纳为间接性和直接性两类。间接性标志物包括GGT、AST、ALT、MCV以及近年备受重视的糖缺乏性转铁蛋白(CDT)。直接的生物标志物包括乙基葡萄糖醛酸苷、全血相关乙醛、磷脂酰乙醇、脂肪酸乙酯等。结论:酒精滥用与依赖的诊断主要依靠详细可靠的病史及躯体检查。同时,恰当地使用一些辅助检查,尤其是一些经济、快速、简便的实验室检查,往往可以快速筛选出可疑的阳性病例。 Objective: To review the progress in research on biomarkers of alcohol abuse and dependence. Methods: Literature review based on Medline search and hand-picked references. Results: We highlight the traditional and some novel biomarkers that can be used in clinical and research settings.( 1) Indirect biomarkers,such as GGT,AST,ALT,MCV and the novel biomarker,carbohydrate-deficient transferring( CDT).( 2) Direct biomarkers: such as ethyl glucuronide( EtG),whole blood associated acetaldehyde( WBAA),phosphatidyl ethanol( PEth) and fatty acid ethyl esters( FAEE). Conclusions: The diagnosis of alcohol abuse and dependence rely primarily on careful history taking and physical examination. Appropriate use of some laboratory tests,especially some rapid,simple and cost-effective tests can detect positive cases.
出处 《中国药物滥用防治杂志》 CAS 2014年第4期243-248,共6页 Chinese Journal of Drug Abuse Prevention and Treatment
关键词 生物标记物 酒精滥用 Γ-谷氨酰转肽酶 糖缺乏性转铁蛋白 biomarkers alcohol abuse Gamma-Glutamyltransferase(GGT) carbohydrate-deficient transferring(CDT)
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  • 1World Health Organisation(WHO). Global Status Report on Alcohol and Health(2014) [ EB/OL]. [2014 -05 - 12]. http :// www. who. int/substance abuse/publications/global_alcohol_report/en/.
  • 2Wurst FM, Ailing C, Aradottir S, et al. Emerging biomarkers : new directions and clinical applications [ J ]. Alcohol Clin Exp Res, 2005, 29 (3) : 465 - 473.
  • 3Ingall GB. Alcohol biomarkers[J]. Clin Lab Med, 2012, 32(3) : 391 -406.
  • 4Wurst FM, Thon N, Weinmann W, et al. What ethanol metabolites as biological markers tell us about alcohol use( J]. Wien Med Wochenschr, 2014, 164(1 -2) : 25 -33.
  • 5Thon N, Weinmann W, Yegles M, et al. Direct metabolites of ethanol as biological markem of alcohol use : basic aspects and applications[J]. Fortschr Neurol Psychiatr, 2013, 81 (9) : 493 -502.
  • 6Helander A, Tabakoff B. Biochemical markers of alcohol use and abuse : experiences from the Pilot Study of the WHO/ISBRA Collaborative Project on state and trait markers of alcohol. International Society for Biomedical Research on Alcoholism [ J ]. Alcohol Alcohol, 1997, 32(2) : 133 -144.
  • 7Bertholet N, Winter MR, Cheng DM, et al. How accurate are blood( or breath) tests for identifying self - reported heavy drinking among people with alcohol dependence[ J]. Alcohol Alcohol, 2014, 49(4) : 423 -429.
  • 8Litten RZ, Bradley AM, Moss HB. Alcohol biomarkers in applied settings: recent advances and future research opportunities [ J ].Alcohol Clin Exp Re.s, 2010, 34(6) : 955 -967.
  • 9Joya X, Friguls B, Ortigosa S, et al. Determination of maternal -fetal biomarkers of prenatal exposure to ethanol: a review [ J ]. J Pharm Biomed Anal, 2012, 69:209-222.
  • 10Reynaud M, Schellenberg F, Loisequx - Meunier MN, et al. Objective diagnosis of alcohol abuse: compared values of carbohydrate - deficient transferrin ( CDT), gamma - glutamyl transferase (GGT), and mean corpuscular volume (MCV) [ J ]. Alcohol Clin Exp Res, 2000, 24(9) : 1414 -1419.

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