纤溶酶治疗短暂性脑缺血发作临床疗效观察

Clinical observation about the therapeutic effect of fibrinolytic enzyme on transient ischemic attack

目的探讨纤溶酶对短暂性脑缺血发作(TIA)患者的治疗效果,并探讨纤溶酶对血浆纤维蛋白原浓度的影响。方法 TIA患者80例,随机分为观察组和对照组各40例,观察组给予纤溶酶300U静脉点滴1次/d持续14d,对照组给予舒血宁注射液20ml静脉点滴1次/d持续14d,两周后比较两组患者临床治疗效果,并比较治疗前后两组患者血浆纤维蛋白原水平变化情况。结果与对照组相比,观察组患者治疗总有效率较对照组明显增高,差异有统计学意义(P<0.05);观察组在降低纤维蛋白原方面优于对照组,差异有统计学意义(P<0.05)。结论纤溶酶对控制TIA发作有明显疗效,并能降低血中纤维蛋白原水平,对预防脑梗死的发生起到作用。

Objective To investigate the treatment effect of fibrinolytic enzyme in patients with transient ischemic attack （TIA）, and to investigate the effect of fibrinolytic enzyme on fibrinogen. Methods Patients with transient ischemic attack were randomly divided into two groups,one group received treatment of fibrinolytic enzyme 300u Intravenous drip 1/day for 14 days（The treatment group,n=40）, the other group received treatment of shuxuening injection 20ml intravenous drip 1/day for 14 days（The control group,n=40）. Compare two groups of patients with the clinical effect after two weeks,and compare the two groups of patients before and after treatment plasma fibrinogen level changes. Results Compared with the control group,treatment group total effective rate was significantly higher,the difference was statistically significant （P〈0.05）;The treatment group is better than that of control group in terms of reduced fibrinogen,the difference was statistically significant（P〈0.05）. Conclusions Fibrinolytic enzyme to control the onset of TIA has obvious curative effect,and can lower fibrinogen levels in the blood,to prevent the occurrence of cerebral infarction.