浅析医院人血白蛋白临床合理用药管理

Analysis on Clinical Application of Human Albumin in Guangxi Guidong People′s Hospital

目的 调研我院人血白蛋白的使用情况,为完善医院人血白蛋白临床合理用药管理提供参考.方法 取我院2013年应用人血白蛋白的住院患者病历,对患者年龄、科室分布、用量、用药理由、用药前血清白蛋白浓度等进行统计与分析,并与人血白蛋白说明书和美国大学医院联合会关于人血白蛋白的使用标准进行比较.结果 我院15个临床科室涉及15类疾病使用人血白蛋白,用量较大的主要是肝胆疾病的患者;在个人用量分布方面,以使用30～40 g的患者最多;用药理由以低蛋白血症所占比例最大,达51.66％;使用人血白蛋白前患者血清白蛋白分布主要集中在21～30 g·L-1范围内.结论 医院人血白蛋白的使用较广泛,且存在不合理使用的可能性,须加强人血白蛋白使用各环节的监管,提高合理用药水平.

Objective To investigate and study the application of human albumin in our hospital, in order to provide reference for the rational clinical drug use management. Methods Medical records of patients administered with human albumin in our hospital in 2013 were collected, and statistical analysis was conducted on the age of patients, department distribution, dosage, medication and serum albumin concentration before medication. The results were then compared with human albumin instructions as well as its usage standard defined by the USA University Hospital Consortium. Results In the 15 clinical departments of our hospital, human albumin was administrated in treatment of 15 diseases, and patients with hepatobiliary disease tended to have large consumptions; in the aspect of personal dosage distribution, most patients used 30-40 g; medication due to hypoproteinemia accounted for the largest proportion, up to 51.66% ; the serum albumin concentrations in patients before administration of human albumin were mainly in the range of 21-30 g · L^-1. Conclusion There was a wide use of human albumin in the hospital, with possibility of irrational use. Therefore it is necessary to strengthen the supervision, and to improve the level of rational use of human albumin.