心血管高危患者踝臂指数与血尿酸水平的相关性分析

Association between ankle-brachial index and serum uric acid level in patients at high risk of cardiovascular diseases

目的探讨心血管高危患者踝臂指数与血尿酸水平的相关性。方法选取高血压和(或)糖尿病患者363例,将单纯原发性高血压189例作为高血压组、原发性高血压合并2型糖尿病123例作为合并组和单纯2型糖尿病51例作为糖尿病组,均常规治疗,检测患者踝臂指数(ABI)、血尿酸和其他心血管疾病危险因素,并应用偏相关分析血尿酸、ABI与其他临床指标相关性。结果 3组收缩压、舒张压、TG、HDL-C、糖化血红蛋白(HbA1c)比较,差异有统计学意义(P<0.05)。高血压组和糖尿病组ABI高于合并组(1.12±0.09和1.11±0.07 vs 0.93±0.11,P=0.012)。校正高血压、糖尿病病史、年龄、性别、体质量指数、TG、TC、HDL-C、LDL-C、HbA1c、收缩压、舒张压等的影响因素后,ABI与血尿酸呈负相关(r=-0.235,P=0.012)。结论心血管高危患者的ABI与血尿酸可能存在相关性。

Objective To investigate the association between ankle-brachial index（ABI）and serum uric acid（SUA）level in patients at high risk of cardiovascular diseases.Methods Three hundred and sixty-three patients with hypertension and diabetes mellitus（DM）were divided into hypertension group（n=189）,hypertension plus DM group（n=123）,and DM group（n=51）.Their ABI was assayed,SUA level was measured,and other risk factors for cardiovascular diseases were detected such as BMI,systolic and diastolic pressure,serum levels of TG,TC,HDL-C,LDL-C and HbA1 c.Association of SUA level and ABI with other clinical indexes was analyzed by partial correlation analysis.Results The systolic and diastolic pressure,serum levels of TG,HDL-C and HbA1 cwere significantly different in 3groups（P0.05）.The ABI was significantly higher in hypertension group and DM group than in hypertension plus DM group,and negatively related with SUA level after adjustment for hypertension and DM history,age,gender,BMI,serum levels of TG,TC,HDL-C,LDL-C and HbA1 c,systolic and diastolic pressure（r=-0.235,P=0.012）.Conclusion ABI is associated with SUA level in patients at high risk of cardiovascular diseases.