老年男性血清抵抗素水平与外周动脉硬化闭塞症的关系

Relation between serum resistin level and peripheral artery occlusive disease in elderly males

目的探讨老年男性血清抵抗素水平与外周动脉硬化闭塞症(PAOD)的关系。方法选择843例老年男性患者,分为PAOD组165例和非PAOD组678例。检测血清抵抗素及C反应蛋白水平,进行相关分析。结果PAOD组血清抵抗素水平明显高于非PAOD组[(7.26±2.94)ng/L vs(6.49±3.09)ng/L,P<0.05]。血清抵抗素水平与C反应蛋白和HDL-C独立相关(β=0.058,β=-0.810,P<0.05)。抵抗素是PAOD的独立危险因素(P=0.004)。结论老年男性PAOD患者血清抵抗素水平升高,血清抵抗素水平可能是PAOD发病的预测因素。

Abstratct：Objective To study the relation between serum resistin level and peripherial arterial occlusive disease（PAOD）in elderly males.Methods Eight hundred and forty-three elderly male patients were divided into PAOD group（n=165）and non-PAOD group（n=678）.Their serum levels of resistin and CRP were mesured and analyzed by correlation analysis.Results The serum resistin level was significantly higher in PAOD group than in non-PAOD group（7.26±2.94ng/Lvs6.49±3.09ng/L,P〈0.05）and independlty related with the serum CRP and HDL-C level（P〈0.05）.The incidence of PAOD increased with the serum resistin level,indicating that resistin was an independent risk factor for PAOD.Conclusion Serum resistin level is significantly higher in elderly male PAOD patients and may be a predictive factor for PAOD.