全瓷冠修复对高血糖患者龈沟液成分影响的分析

Effect of hyperglycemia on gingival crevicular fluid after restoration of ceramic crown

目的:探讨高血糖对全瓷冠固定修复后龈沟液成分的影响。方法:选取近两年在我院口腔修复科就诊的40-50岁,需进行全瓷单冠修复的患者80例为受试对象,其中男性40例,女性40例,常规牙周洁治后采用全瓷单冠修复,分别在修复前以及修复后2个月检测基牙龈沟液的分泌量以及碱性磷酸酶,白细胞介素1β和肿瘤坏死因子α水平。结果:正常血糖患者全瓷修复后2个月基牙龈沟液分泌量,碱性磷酸酶,白细胞介素1和肿瘤坏死因子α水平均无明显升高。高糖组修复后2个月基牙龈沟液分泌量,白细胞介素1和肿瘤坏死因子α显著高于修复前,但碱性磷酸酶水平与修复前比较差异无统计学意义。结论:高糖环境可使全瓷冠修复后患者龈沟液分泌量增加,相关炎性因子表达增高。

Objective： To investigate the effect of hyperglycemia on gingival crevicular fluid after restoration of ceramic crown. Method： 80 patients（40 male and 40 female） were randomly selected from the 40 to 50-year-old patients treated in our department in the past two years who were indicated for single ceramic crown. All the patients were treated with routine periodontal prophylaxis and restoration of all-ceramic crowns. The gross secretory volume of gingival crevicular fluid, ALP,IL-1 and TNF-α were measured before and 2 months after restoration. Results： Among patients with normal blood glucose,there were no significant changes on gross secretory volume of gingival crevicular fluid, ALP, IL-1 and TNF-αlevels 2months after restoration of all-ceramic crowns. Among patients with hyperglycemia, gross secretory volume of gingival crevicular fluid, IL-1 and TNF-αlevels significantly increased 2 months after restoration of all-ceramic crowns, but level of ALP did not change significantly. Conclusion： Hyperglycemia could promote gingival crevicular fluid secretion, and IL-1,TNF-αlevels in gingival crevicular fluid after restoration of ceramic crown.