心脏离子通道病基础研究给临床应用带来的获益

Channelopathies:benefits from basic research to clinical management

心脏离子通道疾病的分子研究已取得瞩目成效,已证实绝大多数离子通道疾病与基因变异相关。基因检测结果结合临床表型决定临床用药,给这类患者带来了生存的希望。本文就最近的相关基础和临床研究进展,对常见而重要的离子通道病的机制与临床治疗间的相关性进行介绍。

It has been susggeted that great advances have been made in molecular study of channelopathles and the majority of the disease have been associateid with gene mutations. Combining genetic testing results with clinical phenotype to guide the regimen improve the efficiacy of treatment. This review summaries the progression in both basic and clinical research of channelopathies and introduces the relation between the phathogenesis and clinical management in several common channelopathies.