间质化疗在乳腺癌术中应用的临床意义

Clinical significance of interstitial chemotherapy applied in breast cancer

目的探讨乳腺癌术中放置氟尿嘧啶植入剂间质化疗的临床意义。方法60例行乳腺癌改良根治术患者按术中是否使用氟尿嘧啶植入剂分为治疗组（40例）和对照组（20例）。对照组常规手术治疗，治疗组在常规手术后，蒸馏水冲洗创面，分别在肿瘤区域下方、胸大小肌间、腋窝血管下0．5cm均匀放置氟尿嘧啶植入剂（剂量0．4g）。观察两组术后骨髓抑制、肝肾功能、胃肠道反应、皮瓣坏死、皮下积液、局部复发等情况。结果两组骨髓抑制、肝肾功能异常、皮瓣坏死、皮下积液及胃肠道反应发生率比较差异无统计学意义（P〉0．05）。治疗组局部复发率低于对照组[0比20．0％（4／20）]，差异有统计学意义（P〈0．05）。结论乳腺癌改良根治术中应用氟尿嘧啶植入剂是安全有效的。

Objective To explore the clinical significance of interstitial chemotherapy applied in breast cancer. Methods Sixty breast cancer patients with modified radical mastectomy were divided into treatment group （40 cases） and control group （20 cases） according to whether using fluorouracil implants. The control group was given conventional treatment. In treatment group, distilled water washed the wound after conventional treatment,and fluorouracil implants （0.4 g） was placed below local tumor,between pectoralis major and peetoralis minor, below 0.5 cm axillary vessel. The bone marrow suppression,liver and renal function,gastrointestinal reaction, skin flap necrosis,subcutaeous hydrops,local recurrence were observed in the 2 groups. Results There were no significant differences in the rates of bone marrow suppression,liver and renal function abnormal, skin flap necrosis, subeutaeous hydrops and gastrointestinal reaction between treatment group and control group（P 〉 0.05 ）. The rate of local recurrence in treatment group was significantly lower than that in control group [0 vs. 20.0%（4/20） ] ,there was statistical difference （P 〈 0.05）. Conclusion Intraoperative application of fluorouracil implants is safe and effective in modified radical mastectomy of breast cancer.